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首页> 外文期刊>International journal of antimicrobial agents >Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection
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Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection

机译：单独使用左氧氟沙星和地红霉素以及与利福平联用治疗实验性鼠流产布鲁氏菌感染的疗效

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摘要

The efficacy of levofloxacin and dirithromycin, alone and in combination with rifampicin in the treatment of experimental brucellosis was investigated. Seventy adult white male mice were infected intraperitoneally with Brucella abortus S544 standard strain. Four of the animals were sacrificed on the 21st day of inoculation for infection control. The remaining 66 mice were randomised into treatment and control groups. Following 14 days of treatment the animals were sacrificed and spleen cultures were made. The cure rates were 36.4% for levofloxacin, 27.3% for dirithromycin, 72.7% for rifampicin, 72.7% for levofloxacin + rifampicin and 81.8% for dirithromycin + rifampicin. The results of this study indicate that levofloxacin and dirithromycin are ineffective in the treatment of experimental murine brucellosis as monotherapy or in combination with rifampicin. (C) 2003 Published by Elsevier B.V. and the International Society of Chemotherapy. [References: 15]
机译：研究了左氧氟沙星和地红霉素单独或与利福平联用治疗实验性布鲁氏菌病的功效。用腹膜布鲁氏菌S544标准株腹膜感染70只成年白雄性小鼠。在接种的第21天处死四只动物以控制感染。其余66只小鼠随机分为治疗组和对照组。处理14天后，处死动物并进行脾培养。左氧氟沙星的治愈率为36.4％，地红霉素为27.3％，利福平为72.7％，左氧氟沙星+利福平为72.7％，地红霉素+利福平为81.8％。这项研究的结果表明，左氧氟沙星和地红霉素作为单一疗法或与利福平联合治疗对实验性鼠布鲁氏菌病无效。 （C）2003年由Elsevier B.V.和国际化学疗法学会出版。 [参考：15]

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