...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of antimicrobial agents >Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus
【24h】

Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus

机译：在由伊曲康唑易感和耐药烟曲霉菌株引起的中性粒细胞减少的鼠中性粒细胞减少性小鼠模型中，氨基candin（IP960; HMR3270）与两性霉素B，伊曲康唑，卡泊芬净和米卡芬净的活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aminocandin (IP960; HMR3270; NXL201) is a new echinocandin with broad-spectrum in vitro activity against Aspergillus and Candida spp. We compared the activity of aminocandin with that of amphotericin B (AmB), itraconazole (ITC) and caspofungin (CAS) in murine models of disseminated aspergillosis against three strains of A. fumigatus, two of which were fully susceptible (AF293 and A1163) and one was resistant to ITC (AF91). Mice were rendered temporarily neutropenic or persistently neutropenic with cyclophosphamide and were infected intravenously 3 days later. Temporarily neutropenic mice were treated with either intraperitoneal (i.p.) AmB ( 5 mg/kg/dose), oral (p.o.) ITC ( 25 mg/kg/dose), intravenous (i.v.) aminocandin (0.25-10 mg/kg/dose), i.p. aminocandin ( 1 mg/kg/dose) or solvent control for 9 days. Mice were euthanised 11 days post infection and the kidneys and liver were removed for quantitative culture. Following infection with AF293, only aminocandin 5 mg/kg i.v. yielded 100% survival. Aminocandin 1 mg/kg i.v., AmB 5 mg/kg i.p. or ITC 25 mg/kg p.o. were equivalent ( P > 0.05). Aminocandin 5 mg/kg was superior to aminocandin 0.25 mg/kg ( P < 0.0001) as well as all controls ( P < 0.0001) in reducing mortality. Following infection with AF91, only aminocandin at 5 mg/kg and 1 mg/kg i.v. yielded 100% survival, which was superior to ITC, aminocandin 0.25 mg/kg and controls ( all P < 0.0001). In the persistently neutropenic model with A1163, aminocandin, CAS and micafungin (2-10 mg/kg) were all effective at prolonging survival, with some impact on reducing culture burdens, even with alternate-day dosing ( 4 mg/kg). The only fungicidal regimen was aminocandin 5 mg/kg, which sterilised 40% and 50% of mice following infection with AF293 and AF91, respectively. Aminocandin at doses of >= 1 mg/kg is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus.
机译：Aminocandin（IP960; HMR3270; NXL201）是一种新的棘皮菌素，具有广谱的体外抗曲霉和念珠菌的活性。我们比较了在针对三种烟曲霉菌株的弥散性曲霉病小鼠模型中，氨基菌素与两性霉素B（AmB），伊曲康唑（ITC）和卡泊芬净（CAS）的活性，其中两种菌株完全敏感（AF293和A1163），一个对ITC（AF91）有抵抗力。用环磷酰胺使小鼠暂时中性粒细胞减少或持续中性粒细胞减少，并在3天后静脉内感染。用腹膜内（ip）AmB（5 mg / kg /剂量），口服（po）ITC（25 mg / kg /剂量），静脉内（iv）氨基坎定（0.25-10 mg / kg /剂量）治疗临时中性粒细胞减少症小鼠，ip氨基抗生物素蛋白（1 mg / kg /剂量）或溶剂控制9天。感染后第11天对小鼠实施安乐死，取出肾脏和肝脏进行定量培养。用AF293感染后，静脉注射仅5 mg / kg的氨基抗生物素。产生了100％的存活率。静脉注射Aminocandin 1 mg / kg，腹腔注射AmB 5 mg / kg。或ITC 25 mg / kg p.o.相当（P> 0.05）。在降低死亡率方面，5 mg / kg的氨基甜蛋白优于0.25 mg / kg的氨基甜菜碱（P <0.0001）以及所有对照（P <0.0001）。用AF91感染后，仅静脉注射5 mg / kg和1 mg / kg的氨基抗生物素。可产生100％的存活率，优于ITC，0.25 mg / kg的氨基抗白蛋白和对照组（所有P <0.0001）。在具有A1163的持续中性粒细胞减少症模型中，即使使用隔日给药（4 mg / kg），氨基抗生物素，CAS和米卡芬净（2-10 mg / kg）均可有效延长生存期，对减轻培养负担有一定影响。唯一的杀菌方案是5 mg / kg的氨基抗生物素，在感染AF293和AF91后分别对40％和50％的小鼠进行了灭菌。 ≥1 mg / kg剂量的氨基糖胺素在降低由ITC易感和耐药烟曲霉引起的传播感染中的死亡率和器官负担方面非常有效。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号