TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine

Wicha Sebastian G.; Kees Martin G.; Solms Alexander; Minichmayr Iris K.; Kratzer Alexander; Kloft Charlotte

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TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine

机译：TDMx：一种新颖的基于网络的开放访问支持工具，用于优化临床常规中的抗菌药物给药方案

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来源
《International journal of antimicrobial agents》 |2015年第4期|共4页
作者
Wicha Sebastian G.; Kees Martin G.; Solms Alexander; Minichmayr Iris K.; Kratzer Alexander; Kloft Charlotte;
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正文语种 eng
中图分类抗生素;
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1. TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine [J] . Wicha Sebastian G., Kees Martin G., Solms Alexander, International journal of antimicrobial agents . 2015,第4期

机译：TDMx：一种新颖的基于网络的开放访问支持工具，用于优化临床常规中的抗菌药物给药方案
2. The Aspirin Regimens in Essential Thrombocythemia (ARES) phase II randomized trial design: Implementation of the serum thromboxane B 2 assay as an evaluation tool of different aspirin dosing regimens in the clinical setting [J] . Valerio De Stefano, Bianca Rocca, Alberto Tosetto, Blood cancer journal. . 2018,第6期

机译：阿司匹林原发性血小板增多症（ARES）II期随机试验设计：血清血栓素B 2分析的实施作为临床环境中不同阿司匹林给药方案的评估工具
3. Using formative evaluation to improve uptake of a web-based tool to support antimicrobial stewardship [J] . ZaidiS.T.R., ThurskyK.A. Journal of Clinical Pharmacy and Therapeutics . 2013,第6期

机译：使用形成性评估来改善对基于Web的工具的支持以支持抗菌素管理
4. Impact of Drug Selection and Dosing Regimens on GI Tract Concentrations and Antimicrobial Resistance [C] . Conference of the American College of Veterinary Internal Medicine (ACVIM) . 2017

机译：药物选择和给药方案对胃肠道浓度和抗微生物抗性的影响
5. The pharmacodynamics of antimicrobial agents against clinical isolates of Staphylococcus epidermidis in a multiple-dose in vitro pharmacodynamic model [D] . Findlay, Ian Masuce 2001

机译：在多剂量体外药效学模型中，抗菌药物对表皮葡萄球菌临床分离株的药效学
6. An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial [O] . Louise F. Hill, Mark A. Turner, Irja Lutsar, 2020

机译：万古霉素的最佳剂量方案与标准剂量方案相比可用于治疗新生儿和90天以下婴儿革兰氏阳性微生物引起的晚期脓毒症（NeoVanc）：一项随机对照试验的研究方案
7. The bacterial identification and antimicrobial susceptibility testing are usually performed manually. Recently, the number of samples has increased and the need for automatification has grown. BioMerieux has investigated Vitek2 for this purpose. HUSLAB has assigned us to compare the identification and antimicrobial results with respect to routine methods and Vitek2. Furthermore, we evaluate test reactions, ESBL (Extended Spectrum Beta-Lactamase) production and the time what it takes to get results with Vitek2. In this study, we examined a total of 183 bacterial isolates including 76 ESBL-strains, 40 nonfermenting rods, 41 fastidious bacteria and 26 fresh clinical isolates. The results of routine methods were gathered from the patient database and following this, compared to the results given by Vitek2. Vitek2 correctly identified more than 96 f the ESBL-strains and fresh clinical isolates. The results of nonfermenting rods and fastidious bacteri a were 70 oncordant with those of the routine methods. Test reaction results of Api20E were 94 nd Api20NE 70 n concordance with Vitek2 results. Approximately 80 f all Vitek2 antimicrobial results and 90 f ESBL test results were correct. Compared to earlier studies, Vitek2 performed the tests faster than the routine methods. These results suggest that Vitek2 is capable of giving rapid and accurate results. However, nonfermenting rods and fastidious bacteria should be studied further. [O] . Järveläinen Marika, Roslund Iira, Silander Maarit 2006

机译：细菌鉴定和抗菌药敏试验通常是手动进行的。最近，样品的数量增加了，并且对自动化的需求也在增长。 BioMerieux为此进行了Vitek2的研究。 HUSLAB已指派我们比较常规方法和Vitek2的鉴定和抗菌结果。此外，我们还评估了测试反应，ESBL（扩展频谱β-内酰胺酶）的产生以及使用Vitek2获得结果所需的时间。在这项研究中，我们检查了总共183个细菌分离株，包括76个ESBL菌株，40个非发酵棒，41个营养细菌和26个新鲜临床分离株。从患者数据库中收集常规方法的结果，然后将其与Vitek2给出的结果进行比较。 Vitek2正确鉴定出超过96种ESBL菌株和新鲜的临床分离株。与常规方法相比，非发酵棒和精制细菌的结果为70。 Api20E的测试反应结果与Vitek2结果一致为94nd Api20NE 70 n。所有Vitek2抗菌结果约80 f和ESBL测试结果90 f正确。与早期的研究相比，Vitek2的测试速度快于常规方法。这些结果表明Vitek2能够给出快速而准确的结果。但是，应进一步研究非发酵棒和营养细菌。

TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine

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