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首页> 外文期刊>International journal of antimicrobial agents >Intravenous pharmacokinetics of ciprofloxacin in goats
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Intravenous pharmacokinetics of ciprofloxacin in goats

机译：环丙沙星在山羊体内的静脉药代动力学

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The pharmacokinetics of ciprofloxacin in goats was studied following intravenous administration. A single dose of 10 mg/kg was administered as an intravenous bolus, and serum samples were collected at predetermined intervals over a 24 h period. Ciprofloxacin levels were measured using high pressure liquid chromatography and the resulting concentration versus time curve was analyzed using a non linear regression analysis. The data were best represented by a two-compartment pharmacokinetic model With a mean elimination half-life of 2.72 +/- 1.04 h. Mean pharmacokinetic parameters obtained were area under the curve (AUC: 10.320 +/- 5.137 mu g/ml per h), mean residence time (MRT: 3.334 +/- 1.428 h), apparent volume of distribution (Vdss: 3.373 +/- 0.893 1/kg) and total body drug clearance (tCl 19.596 +/- 9.059 ml/min per kg). Ciprofloxacin in goats showed the general pharmacokinetic characteristics of a typical fluoroquinolone antibacterial agent and we recommend a dose of 10 mg/kg to be administered intravenously at 12 h intervals to goats. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved. [References: 12]
机译：静脉内给药后研究了环丙沙星在山羊中的药代动力学。静脉推注单剂量10 mg / kg，并在24小时内以预定间隔收集血清样品。使用高压液相色谱法测量环丙沙星水平，并使用非线性回归分析法分析所得的浓度-时间曲线。数据最好由两室药代动力学模型表示，平均消除半衰期为2.72 +/- 1.04小时。获得的平均药代动力学参数为曲线下面积（AUC：10.320 +/- 5.137μg / ml / h），平均停留时间（MRT：3.334 +/- 1.428 h），表观分布体积（Vdss：3.373 +/-） 0.893 1 / kg）和全身药物清除率（tCl 19.596 +/- 9.059 ml / min / kg）。山羊中的环丙沙星显示出典型氟喹诺酮类抗菌剂的一般药代动力学特征，我们建议以每12小时一次的间隔静脉内给山羊施用10 mg / kg的剂量。 （C）2000 Elsevier Science B.V.和国际化学疗法学会。版权所有。 [参考：12]

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