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首页> 外文期刊>International clinical psychopharmacology >Neuroprotection in Huntington's disease: a 2-year study on minocycline.
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Neuroprotection in Huntington's disease: a 2-year study on minocycline.

机译：亨廷顿氏病的神经保护作用：对米诺环素的2年研究。

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摘要

Huntington's disease (HD), a relentlessly progressive neurodegenerative disorder, is characterized by a clinical triad of psychiatric, cognitive and motor disturbances. The antibiotic minocycline, a caspase inhibitor exhibiting antiapoptotic properties, has been shown to prolong survival in the transgenic mouse model of HD. We administrated minocycline to 14 patients with genetically confirmed HD. The patients were psychiatrically, neurologically and neuropsychologically evaluated at baseline, and after 6 and 24 months of treatment, using the Unified HD Rating Scale and a neuropsychological test battery. After 12 months, three patients were lost to follow-up so that 11 patients were analysed at the endpoint. Minocycline was well tolerated. Unlike the expected natural course of HD, patients exhibited stabilization in general motor and neuropsychological function at endpoint, after improving in the first 6 months. Moreover, we found a significant amelioration of psychiatric symptoms that was not apparentafter the first 6 months. In detail, the Mini-Mental State Examination, the Total Motor Score, the Total Functional Capacity Scale and the Independence Scale, as the most prominent scales in HD, were stabilized after 3 years of treatment. Our results confirm previous animal studies and indicate a neuroprotective effect of this agent in HD. A long-term, double-blind, placebo-controlled trial appears highly warranted for definitively establishing the value of minocycline in HD.
机译：亨廷顿舞蹈病（HD）是一种持续进行性神经退行性疾病，其特征在于临床上存在精神病，认知障碍和运动障碍。抗生素米诺环素是一种具有抗凋亡特性的半胱天冬酶抑制剂，已显示出可以在HD转基因小鼠模型中延长其生存期。我们对14例经遗传学证实的HD的患者给予了米诺环素。使用统一高清评分量表和神经心理学测试电池对患者进行基线，治疗6个月和24个月的精神，神经和神经心理学评估。 12个月后，有3例患者失去随访，因此在终点对11例患者进行了分析。美诺环素的耐受性良好。与预期的HD自然病程不同，患者在最初的6个月中有所改善，在终点时表现出一般运动和神经心理功能的稳定。此外，我们发现精神症状的明显改善在开始的6个月后还没有发现。详细说来，迷你精神状态检查，总运动评分，总功能能力量表和独立性量表（HD）中最突出的量表在治疗3年后稳定下来。我们的结果证实了先前的动物研究，并表明该药物在HD中具有神经保护作用。一项长期的，双盲的，安慰剂对照的试验似乎对于明确确定米诺环素在HD中的价值非常有必要。

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