• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International clinical psychopharmacology >Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression.
【24h】

Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression.

机译：枸sil酸西地那非（Viagra）治疗抑郁症缓解男性勃起功能障碍的功效。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Erectile dysfunction (ED) and depression are highly prevalent and frequently comorbid. Sildenafil effectively treats ED in men with depression and in men taking antidepressants. We evaluated the efficacy of sildenafil in men with depression in remission and ED. Patients with a history of ED when major depressive disorder (MDD) was diagnosed, which persisted after MDD was treated to remission, were randomized to 12 weeks of treatment with sildenafil (50 mg, flexible) or placebo. Efficacy was assessed using intercourse success rates, a global efficacy question (Has treatment improved your erections?), the International Index of Erectile Function (IIEF) and Life Satisfaction Checklist (LSC). By week 12, intercourse success rates were significantly higher among sildenafil- (74%) compared to placebo-treated patients (29%; P=0.0001). About 83% and 34% of sildenafil- and placebo-treated patients, respectively, reported improved erections (odds ratio=9.4, P=0.0001). IIEF scores in the sildenafil group (n=83) were significantly improved compared to those in the placebo group (n=85; P <0.0001). LSC sexual life item improved significantly among sildenafil- versus placebo-treated patients. The most frequently reported adverse events were transient and mild-to-moderate. Sildenafil is an effective and well-tolerated treatment for ED in patients with a history of ED at the time of MDD diagnosis, and which persisted after the MDD was treated to remission.
机译：勃起功能障碍（ED）和抑郁症非常普遍，并经常合并。西地那非可有效治疗抑郁症男性和服用抗抑郁药的男性的ED。我们评估了西地那非对缓解和ED抑郁症男性的疗效。在诊断出患有重度抑郁症（MDD）时有ED史的患者（在MDD缓解后仍存在）被随机分配至接受西地那非（50 mg，软性）或安慰剂治疗12周。使用性交成功率，总体疗效问题（治疗能改善勃起吗？），国际勃起功能指数（IIEF）和生活满意度检查表（LSC）评估疗效。到第12周时，西地那非（74％）的性交成功率显着高于安慰剂治疗的患者（29％; P = 0.0001）。西地那非和安慰剂治疗的患者分别约有83％和34％的勃起得到改善（几率= 9.4，P = 0.0001）。西地那非组（n = 83）的IIEF评分较安慰剂组（n = 85; P <0.0001）有显着改善。西地那非治疗组和安慰剂治疗组的LSC性生活项目明显改善。最常见的不良事件是短暂的和轻度至中度的。西地那非是一种在MDD诊断时有ED史的患者中对ED的有效且耐受性良好的治疗，并且在MDD缓解后仍持续存在。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号