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首页> 外文期刊>International clinical psychopharmacology >Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.
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Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.

机译：使用新型抗精神病药塞多多治疗，可防止迟发性运动效应。

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Conventional antipsychotics are often associated with late-occurring undesirable movement effects. To gain more experience with newer antipsychotic agents, 151 patients in an acute admissions department were switched from treatment with conventional antipsychotics to sertindole between late 1996 and early 1998. Four of these patients had tardive dyskinesia, tardive dystonia and/or tardive akathisia. The effect of changing to sertindole was measured using specific rating scales for undesirable movement effects. Three of the four patients apparently recovered from the movement disorders after switching to sertindole. In one patient, sertindole monotherapy was not sufficient to reduce the movement effects, but combination treatment with tetrabenazine resulted in a greater reduction in extrapyrimidal symptoms. Because these are case reports, no direct conclusions can be drawn. However, the beneficial effect of sertindole on severe, late-occurring movement disorders, as observed in four difficult-to-treat patients, appears to be promising.
机译：常规的抗精神病药通常与后期发生的不良运动效应有关。为了获得更多使用新型抗精神病药的经验，1996年底至1998年初之间，急诊科的151例患者从常规抗精神病药治疗转为使用sertindole。这些患者中有4例患有迟发性运动障碍，迟发性肌张力障碍和/或迟发性静坐症。使用特定的等级量表来测量更改为sertindole的效果，以实现不良的运动效果。四名患者中的三名在转换为塞多度后明显从运动障碍中恢复过来。在一名患者中，单药多效治疗不足以减轻运动影响，但与丁苯那嗪合用可导致更大的锥体外系症状减轻。由于这些都是病例报告，因此无法得出直接结论。然而，如在四名难以治疗的患者中观察到的那样，塞达多尔对严重的迟发性运动障碍的有益作用似乎是有希望的。

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