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首页> 外文期刊>International clinical psychopharmacology >Effectiveness of long-acting paliperidone palmitate in borderline personality disorder
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Effectiveness of long-acting paliperidone palmitate in borderline personality disorder

机译：长效帕潘立酮棕榈酸酯治疗边缘型人格障碍的有效性

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The aim of the present study is to test the efficacy of palmitate paliperidone long-acting injection for patients with borderline personality disorder (BPD). A total of 16 patients with BPD were treated with intramuscular paliperidone palmitate (IMPP) over 12 weeks. Effectiveness measures included the CGI-BPD, HARS, MADRS, BIS-11, and STAXI-2. Functional improvement was assessed using the Global Assessment of Functioning scale. A list of adverse events was provided to clinicians and patients. Treatment with IMPP was associated with a significant average reduction of 1.6 (95% confidence interval: 1192-2008; P > 0.01) in CGI-BPD scores and an average increase of psychosocial functioning as scored by the Global Assessment of Functioning scale of 13.3 (95% confidence interval: 8.35-18.31; P > 0.01) was obtained. The treatment decreased impulsive-disruptive behaviors and improved general functioning. An acceptable tolerance was observed. The average weight gain was clinically irrelevant despite being statistically significant. No other relevant adverse side effects were reported, with the exception of galactorrhea, which required suspension of treatment in three patients. IMPP seems to be a well-tolerated alternative to other second-generation antipsychotics in the treatment of BPD. More controlled studies replicating these results should be proposed in the future. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
机译：本研究的目的是测试棕榈酸酯帕潘立酮长效注射液对边缘性人格障碍（BPD）患者的疗效。共有16名BPD患者在12周内接受了帕潘立酮棕榈酸酯肌肉注射（IMPP）治疗。有效性措施包括CGI-BPD，HARS，MADRS，BIS-11和STAXI-2。使用全球功能评估量表评估功能改善。向临床医生和患者提供了不良事件的清单。 IMPP的治疗与CGI-BPD评分的平均平均降低1.6（95％置信区间：1192-2008; P> 0.01）以及心理功能的平均增加有关（根据全球功能评估量表的13.3（获得95％的置信区间：8.35-18.31; P> 0.01）。该治疗减少了冲动-破坏行为并改善了总体功能。观察到可接受的公差。尽管具有统计学意义，但平均体重增加与临床无关。除溢乳外，未报告其他相关的不良副作用，这需要暂停三名患者的治疗。在BPD的治疗中，IMPP似乎是其他第二代抗精神病药的良好耐受替代品。将来应提出更多重复这些结果的对照研究。版权所有（C）2015 Wolters Kluwer Health，Inc.保留所有权利。

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