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首页> 外文期刊>International clinical psychopharmacology >Effect of a pharmacological intervention on quality of life in patients with obsessive-compulsive disorder.
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Effect of a pharmacological intervention on quality of life in patients with obsessive-compulsive disorder.

机译：药理干预对强迫症患者生活质量的影响。

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Patients with obsessive-compulsive disorder (OCD) not only suffer from obsessive-compulsive symptoms, but also the disorder is associated with aberrant social functioning and a diminished quality of life (QoL). Although studies concerning the effect of treatment interventions on symptoms are common, studies with regard to the effect of treatment interventions on QoL are scarce. We examined the effect of a pharmacological intervention on QoL in 150 patients with OCD. Furthermore, we studied whether two different drugs, venlafaxine and paroxetine, differed in their effect on QoL. Finally, we examined whether any found improvement in QoL was related to improvement in symptoms and/or the baseline self-directedness score, which is one of the character dimensions of the psychobiological model of Cloninger. We demonstrated that QoL, as assessed with the Lancashire Quality of Life Profile, improved following pharmacological intervention, for which paroxetine and venlafaxine appeared to be equally effective. Furthermore, neither improvement in symptoms, nor baseline self-directedness, was associated with the improvement in QoL.
机译：强迫症（OCD）患者不仅患有强迫症，而且与社交功能异常和生活质量（QoL）下降有关。尽管关于治疗干预对症状的影响的研究很普遍，但是关于治疗干预对QoL的影响的研究却很少。我们检查了150例强迫症患者中药理干预对QoL的影响。此外，我们研究了文拉法辛和帕罗西汀这两种不同药物对QoL的影响是否不同。最后，我们检查了QoL的任何发现改善是否与症状和/或基线自我指导得分的改善有关，这是Cloninger心理生物学模型的特征维度之一。我们证明，根据兰开夏郡生活质量档案评估，QoL在药理干预后有所改善，对此帕罗西汀和文拉法辛似乎同样有效。此外，症状改善或基线自我指导均与生活质量的改善无关。

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