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首页> 外文期刊>International clinical psychopharmacology >Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients.
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Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients.

机译：用锂而不是丙戊酸钠进行慢性治疗可增加正常人双相情感障碍患者皮质N-乙酰天冬氨酸的浓度。

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Previous studies have found that treatment with lithium over a 4-week period may increase the concentration of -acetyl-aspartate (NAA) in both bipolar patients and controls. In view of other findings indicating that NAA concentrations may be a good marker for neuronal viability and/or functioning, it has been further suggested that some of the long term benefits of lithium may therefore be due to actions to improve these neuronal properties. The aim of the present study was to utilize H magnetic resonance spectroscopy ( H MRS) to further examine the effects of both lithium and sodium valproate upon NAA concentrations in treated euthymic bipolar patients. In the first part of the study, healthy controls ( =18) were compared with euthymic bipolar patients (type I and type II) who were taking either lithium ( =14) or sodium valproate ( =11), and NAA : creatine ratios were determined. In the second part, we examined a separate group of euthymic bipolar disorder patients taking sodium valproate ( =9) and compared these to age- and sex-matched healthy controls ( =11), and we quantified the exact concentrations of NAA using an external solution. The results from the first part of the study showed that bipolar patients chronically treated with lithium had a significant increase in NAA concentrations but, in contrast, there were no significant increases in the sodium valproate-treated patients compared to controls. The second part of the study also found no effects of sodium valproate on NAA concentrations. These findings are the first to compare NAA concentrations in euthymic bipolar patients being treated with lithium or sodium valproate. The results support suggestions that longer-term administration of lithium to bipolar patients may increase NAA concentrations. However, the study suggests that chronic administration of sodium valproate to patients does not lead to similar changes in NAA concentrations. These findings suggest that sodium valproate and lithium may not share a common mechanism of action in bipolar disorder involving neurotrophic or neuroprotective effects.
机译：先前的研究已经发现，在两周内用锂治疗可能会增加双相情感障碍患者和对照组的-乙酰天门冬氨酸（NAA）浓度。鉴于其他发现表明NAA浓度可能是神经元生存能力和/或功能的良好标志，因此进一步建议锂的某些长期益处可能归因于改善这些神经元特性的作用。本研究的目的是利用H磁共振波谱（H MRS）进一步检查丙戊酸锂和丙戊酸钠对治疗的正常人双相情感障碍患者NAA浓度的影响。在研究的第一部分中，将健康对照（= 18）与服用锂（= 14）或丙戊酸钠（= 11）的常态双相情感障碍患者（I型和II型）进行比较，NAA与肌酸的比率为决心。在第二部分中，我们检查了另一组服用丙戊酸钠的正常人双相情感障碍患者（= 9），并将其与年龄和性别相匹配的健康对照（= 11）进行了比较，并使用外部定量了NAA的确切浓度。解。研究第一部分的结果表明，长期接受锂治疗的双相情感障碍患者的NAA浓度显着增加，但是与对照组相比，丙戊酸钠治疗的患者无明显增加。研究的第二部分也没有发现丙戊酸钠对NAA浓度没有影响。这些发现是第一个比较用丙戊酸锂或丙戊酸钠治疗的常态双相情感障碍患者中NAA浓度的方法。该结果支持以下建议：长期向双相型患者服用锂可能会增加NAA浓度。但是，研究表明，向患者长期服用丙戊酸钠不会导致类似的NAA浓度变化。这些发现表明，丙戊酸钠和锂可能在涉及神经营养或神经保护作用的双相情感障碍中没有共同的作用机制。

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