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首页> 外文期刊>International Journal of Cell Biology >Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival
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Implications of Therapy-Induced Selective Autophagy on Tumor Metabolism and Survival

机译：治疗诱导的选择性自噬对肿瘤代谢和生存的影响

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Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective forms of autophagy. These selective forms of autophagy, including mitophagy, nucleophagy, and ubiquitin-mediated autophagy, counteract apoptotic signals by removing damaged cellular structures and by reprogramming cellular energy metabolism to cope with therapeutic stress. As a result, the efficacies of numerous current cancer therapies may be improved by combining them with adjuvant treatments that exploit or disrupt key metabolic processes induced by selective forms of autophagy. Targeting these metabolic irregularities represents a promising approach to improve clinical responsiveness to cancer treatments given the inherently elevated metabolic demands of many tumor types. To what extent anticancer treatments promote selective forms of autophagy and the degree to which they influence metabolism are currently under intense scrutiny. Understanding how the activation of selective forms of autophagy influences cellular metabolism and survival provides an opportunity to target metabolic irregularities induced by these pathways as a means of augmenting current approaches for treating cancer.
机译：越来越多的证据表明，旨在触发肿瘤细胞凋亡的疗法会引起线粒体去极化，核损伤以及错误折叠的蛋白质聚集体的积累，从而导致自噬选择性形式的激活。这些选择性吞噬的选择性形式，包括线粒体吞噬，核吞噬和泛素介导的自噬，通过去除受损的细胞结构并通过重新编程细胞能量代谢以应对治疗压力来抵消凋亡信号。结果，通过将它们与利用或破坏由选择性自噬形式诱导的关键代谢过程的辅助治疗相结合，可以改善许多当前癌症疗法的功效。考虑到许多肿瘤类型固有的新陈代谢需求增加，针对这些新陈代谢的不规律性代表了一种改善临床对癌症治疗反应性的有前途的方法。目前，抗癌治疗在多大程度上促进了自噬的选择性形式，并且它们在多大程度上影响了新陈代谢，目前正受到严格​​的审查。了解选择性吞噬的选择性形式的激活如何影响细胞代谢和存活，提供了靶向这些途径引起的代谢异常的机会，以此作为增强当前治疗癌症方法的手段。

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