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首页> 外文期刊>International Journal of Cell Biology >Stable Differences in Intrinsic Mitochondrial Membrane Potential of Tumor Cell Subpopulations Reflect Phenotypic Heterogeneity
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Stable Differences in Intrinsic Mitochondrial Membrane Potential of Tumor Cell Subpopulations Reflect Phenotypic Heterogeneity

机译：肿瘤细胞亚群内源性线粒体膜电位的稳定差异反映了表型异质性

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摘要

Heterogeneity among cells that constitute a solid tumor is important in determining disease progression. Our previous work estab-lished that, within a population of metastatic colonic tumor cells, there are minor subpopulations of cells with stable differences in their intrinsic mitochondrial membrane potential (Δψm), and that these differences in &I'm are linked to tumorigenic phenotype. Here we expanded this work to investigate primary mammary, as well as colonic, tumor cell lines. We show that within a primary mammary tumor cell population, and in both primary and metastatic colonic tumor cell populations, there are subpopulations of cells with significant stable variations in intrinsic Δψm. In each of these 3 tumor cell populations, cells with relatively higher intrinsic AWm exhibit phenotypic properties consistent with promotion of tumor cell survival and expansion. However, additional properties associated with invasive potential appear in cells with higher intrinsic ΔWm only from the metastatic colonic tumor cell line. Thus, it is likely that differences in the intrinsic Aψm among cells that constitute primary mammary tumor populations, as well as primary and metastatic colonic tumor populations, are markers of an acquired tumor phenotype which, within the context of the tumor, influence the probability that particular cells will contribute to disease progression.
机译：构成实体瘤的细胞之间的异质性对于确定疾病进展很重要。我们以前的工作表明，在转移性结肠肿瘤细胞群中，有少量亚细胞，其固有线粒体膜电位（Δψm）具有稳定的差异，并且＆I'm中的这些差异与致瘤表型有关。在这里，我们扩展了这项工作，以研究原发性乳腺以及结肠肿瘤细胞系。我们显示，在原发性乳腺肿瘤细胞群内，以及在原发性和转移性结肠肿瘤细胞群中，都有内在Δψm具有显着稳定变化的细胞亚群。在这3个肿瘤细胞群的每一个中，具有相对较高的固有AWm的细胞表现出与促进肿瘤细胞存活和扩增一致的表型特性。然而，仅在转移性结肠肿瘤细胞系中，具有更高内在ΔWm的细胞中才会出现与侵袭潜能相关的其他特性。因此，构成原发性乳腺肿瘤群体的细胞以及原发性和转移性结肠肿瘤群体的内在Aψm的差异很可能是获得性肿瘤表型的标志，在肿瘤的背景下，该表型会影响特定的细胞将促进疾病的发展。

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