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首页> 外文期刊>International Journal of Cell Biology >Three-Axis Model for Atg Recruitment in Autophagy against Salmonella
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Three-Axis Model for Atg Recruitment in Autophagy against Salmonella

机译：沙门氏菌自噬的Atg补充的三轴模型

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摘要

Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella- containing vacuole (SCV). In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella. The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and P13-kinase activity, LC3 is still recruited to the vicinity of Salmonella. We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atgl6L complex.
机译：鼠伤寒沙门氏菌鼠伤寒沙门氏菌进入上皮细胞并在那里停留。在上皮细胞内，一部分细菌被自噬体样双膜结构所包围，并且它们仍驻留在含沙门氏菌的液泡（SCV）中。在本文中，我们将讨论如何在沙门氏菌附近募集自噬机器。这种双层膜的形成需要Atg9L1和FIP200;这些蛋白对于PI3激酶复合物的自噬特异性募集很重要。在没有Atg9L1，FIP200和P13激酶活性的情况下，LC3仍被募集到沙门氏菌附近。我们提出了一种新型模型，其中LC3募集的机制与隔离膜的产生是分开的。 Atg募集中至少存在三个轴：ULK1复合体，Atg9L1和Atgl6L复合体。

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