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首页> 外文期刊>International Journal of Cell Biology >Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases
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Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases

机译：网状蛋白1C：治疗不同神经元疾病的新希望

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摘要

Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.
机译：网状蛋白（RTN）是一组位于ER上的膜蛋白，已知调节ER结构和功能。多项研究表明，RTN参与了不同的重要细胞功能，例如钙稳态的改变，内质网应激介导的细胞死亡和自噬。已经证明RTN通过特异性蛋白质的相互作用或调节而发挥癌症特异性的促凋亡功能。网状蛋白还涉及不同的信号传导途径，这是几种神经退行性疾病的发病机理的基础。在本文中，我们讨论了越来越多的证据，这些证据将RTN-1C蛋白鉴定为治疗诸如癌症或神经退行性疾病等不同病理的有希望的靶标。

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