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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Muscle contraction: viscous-like frictional forces and the impulsive model
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Muscle contraction: viscous-like frictional forces and the impulsive model

机译：肌肉收缩：类似粘性的摩擦力和冲动模型

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Apart from a few experimental studies muscle viscosity has not received much recent analytical attention as a determinant of the contractile process. This is surprising, since any muscle cell is 80% water, and may undergo large shape changes during its working cycle. Intuitively one might expect the viscosity of the solvent to be an important determinant of the physiological activity of muscle tissue. This was apparent to pioneers of the study of muscle contraction such as Hill and his contemporaries, whose putative theoretical formulations contained terms related to muscle viscosity. More recently, though, a hydrodynamic calculation by Huxley, using a solvent viscosity close to that of water, has been held to demonstrate that viscous forces are negligible in muscle contraction. We have re-examined the role of viscosity in contraction, postulating impulsive acto-myosin forces that are opposed by a viscous resistance between the filaments. The viscous force required, 10(4) times the hydrodynamic estimate, is close to recent experimental measurements, themselves 10(2)-10(3) times the hydrodynamic estimate. This also agrees with contemporary measurements of cytoplasmic viscosity in other biological cells using magnetic bead micro-rheometry. These are several orders of magnitude greater than the viscosity of water. In the course of the analysis we have derived the force-velocity equation for an isolated half-sarcomere containing a single actin filament for the first time, and from first principles. We conclude that muscle viscosity is indeed important for the contractile process, and that it has been too readily discounted. (C) 2000 Elsevier Science B.V. All rights reserved. [References: 31]
机译：除了一些实验研究外，肌肉黏度作为收缩过​​程的决定因素还没有得到最近的分析关注。这是令人惊讶的，因为任何肌肉细胞都含有80％的水，并且在其工作周期中可能会发生较大的形状变化。凭直觉，人们可能期望溶剂的粘度是肌肉组织生理活性的重要决定因素。对于肌肉收缩研究的先驱者，例如希尔和他的同时代人，这是显而易见的，他们的推定理论公式包含与肌肉黏度有关的术语。但是，最近，赫x黎（Huxley）使用接近水的溶剂粘度进行了流体力学计算，以证明粘性力在肌肉收缩中可忽略不计。我们已经重新检查了粘度在收缩中的作用，推测了冲动肌动球蛋白力与细丝之间的粘性阻力相反。所需的粘性力是流体力学估算值的10（4）倍，接近于最近的实验测量值，它们本身是流体力学估算值的10（2）-10（3）倍。这也与使用磁珠微流变仪对其他生物细胞中细胞质粘度的当代测量结果一致。这些比水的粘度大几个数量级。在分析过程中，我们从第一原理首次得出了一个包含单肌动蛋白丝的孤立半肌节的力-速度方程。我们得出的结论是，肌肉粘度对于收缩过程确实很重要，并且已经很容易被忽视。 （C）2000 Elsevier Science B.V.保留所有权利。 [参考：31]

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