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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Development of the selective adsorbent for EDA containing fibronectin using heparin immobilized cellulose
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Development of the selective adsorbent for EDA containing fibronectin using heparin immobilized cellulose

机译：用固定化肝素的纤维素开发含纤连蛋白的EDA选择性吸附剂

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摘要

We have noticed that extra domain A containing fibronectin (EDA(+)FN) is closely related to inflammatory diseases and accordingly investigated a selective adsorbent to remove EDA(+)FN, which may increase the severity of the symptoms, from the plasma of rheumatoid arthritis (RA) patients. Three types of heparin immobilized cellulose (HC) were prepared and their adsorptive properties were evaluated by batchwise adsorption tests. The results showed that EDA(+)FN was adsorbed more efficiently than total FN on HC. In particular HC in which heparin was immobilized to amino residue had an excellent capacity. The adsorption rates of EDA(+)FN, total FN and antithrombin-III were 89, 15 and 17% respectively. This adsorbent is extremely useful in selectively removing EDA(+)FN from plasma. (C) 1998 Elsevier Science B.V. All rights reserved. [References: 14]
机译：我们注意到，包含纤连蛋白（EDA（+）FN）的额外域A与炎症疾病密切相关，因此研究了选择性吸附剂以去除类风湿血浆中的EDA（+）FN，这可能会增加症状的严重性关节炎（RA）患者。制备了三种固定化肝素的纤维素（HC），并通过分批吸附试验评估了它们的吸附性能。结果表明，EDA（+）FN比HC上的总FN吸附效率更高。特别是将肝素固定在氨基残基上的HC具有优异的容量。 EDA（+）FN，总FN和抗凝血酶III的吸附率分别为89％，15％和17％。这种吸附剂在从血浆中选择性去除EDA（+）FN方面非常有用。 （C）1998 Elsevier Science B.V.保留所有权利。 [参考：14]

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