Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein

Gao Z.; Li F.; Wu G.; Zhu Y.; Yu T.; Yu S.

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Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein

机译：铰链区，环3和环4在大肠杆菌环状AMP受体蛋白激活中的作用

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The cAMP receptor protein (CRP) requires cAMP for an allosteric change and regulates more than 150 genes in Escherichia coli. In this study, the modular half of cAMP receptor protein was used to investigate the allosteric signal transmission pathway induced by cAMP binding. The activation of CRP upon cAMP binding is indicated to be realignment of the two subunits within the CRP dimer. The interaction of loop 3 and Phe136 do not involve in signal transmission.

机译：cAMP受体蛋白（CRP）需要cAMP才能发生变构变化，并调节大肠杆菌中的150多个基因。在这项研究中，使用cAMP受体蛋白的一半模块来研究cAMP结合诱导的变构信号传递途径。 cAMP结合后CRP的激活表明是CRP二聚体中两个亚基的重新排列。回路3和Phe136的相互作用不涉及信号传输。

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《International Journal of Biological Macromolecules: Structure, Function and Interactions》 |2012年第1期|共6页
作者
Gao Z.; Li F.; Wu G.; Zhu Y.; Yu T.; Yu S.;
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正文语种 eng
中图分类生物大分子的结构和功能;
关键词
CAMP; CAMP binding motif; CAMP receptor protein; Conformational change;

机译：CAMP;CAMP结合基序;CAMP受体蛋白;构象变化;

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1. Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein [J] . Gao Z., Li F., Wu G., International Journal of Biological Macromolecules: Structure, Function and Interactions . 2012,第1期

机译：铰链区，环3和环4在大肠杆菌环状AMP受体蛋白激活中的作用
2. Transcription activation by the Escherichia coli cyclic AMP receptor protein: determinants within activating region 3. [J] . Rhodius VA, Busby SJ Journal of Molecular Biology . 2000,第2期

机译：大肠杆菌环状AMP受体蛋白的转录激活：激活区域3中的决定簇。
3. Interactions between activating region 3 of the Escherichia coli cyclic AMP receptor protein and region 4 of the RNA polymerase sigma(70) subunit: application of suppression genetics. [J] . Rhodius VA, Busby SJ Journal of Molecular Biology . 2000,第2期

机译：大肠杆菌环AMP受体蛋白的激活区域3和RNA聚合酶sigma（70）亚基的区域4之间的相互作用：抑制遗传学的应用。
4. Siderophore Receptor and Porin Protein Technology for Control of Salmonella and Escherichia coli 0157:H7 in Cattle [C] . E.T. Stevens, D.U. Thomson Annual Conference of American Association of Bovine Practitioners . 2005

机译：西参受体和孔素蛋白质技术控制沙门氏菌和大肠杆菌0157：H7在牛中
5. Transcriptional activation by natural and artificial cAMP receptor proteins in Escherichia coli. [D] . Langdon, Robert Christopher. 2001

机译：大肠杆菌中天然和人工cAMP受体蛋白的转录激活。
6. Roles of Cyclic AMP Receptor Protein and the Carboxyl-Terminal Domain of the α Subunit in Transcription Activation of the Escherichia coli rhaBAD Operon [O] . Carolyn C. Holcroft, Susan M. Egan 2000

机译：环AMP受体蛋白和α亚基的羧基末端结构域在大肠杆菌rhaBAD操纵子转录激活中的作用
7. Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein [O] . Tamara A. Belyaeva, Joseph T. Wade, Christine L. Webster, 2000

机译：大肠杆菌Melab启动子的转录激活：Melr和环状AMP受体蛋白的作用

Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein

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