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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >The inhibitory effect of a polysaccharide from codonopsis pilosula on tumor growth and metastasis in vitro
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The inhibitory effect of a polysaccharide from codonopsis pilosula on tumor growth and metastasis in vitro

机译：党参多糖对体外肿瘤生长和转移的抑制作用

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摘要

In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells.
机译：在这项研究中，我们从党参的根中制备了酸性多糖（CPPA）。在体外检查了CPPA对肿瘤细胞生长，侵袭和迁移的影响。通过伤口愈合，transwell和细胞粘附试验评估，CPPA不仅在体外对人上皮性卵巢癌HO-8910细胞的侵袭和迁移能力产生了有效的抑制作用，而且对肿瘤细胞具有有效的抗增殖作用。此外，CPPA处理也减弱了HO-8910细胞上的CD44表达。因此，我们的结果表明，CPPA可能是通过抑制肿瘤细胞的侵袭，迁移和粘附以及肿瘤细胞上CD44的表达来预防肿瘤转移的潜在候选化合物。

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