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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Nanoparticles based on albumin: Preparation, characterization and the use for 5-flurouracil delivery
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Nanoparticles based on albumin: Preparation, characterization and the use for 5-flurouracil delivery

机译：基于白蛋白的纳米颗粒：制备，表征及其在5-氟尿嘧啶递送中的用途

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摘要

The aim of the study was to formulate and evaluate nanoparticles based on albumin to deliver 5-fluorouracil. The nanoparticles were prepared by coacervation method. The nanoparticles were characterized for particle size, surface charge, size distribution and drug loading capacity. The drug loading capacity varied from 4.22% to 19.8% (w/w). The mean particle size was 141.9. nm and surface charge was -30.3. mV. The drug loaded particles exerted a bi-phasic release pattern with an initial burst effect followed by a sustained release in pH 7.4 phosphate buffer. The drug release was first order diffusion controlled and the mechanism was Fickian. The drug loaded nanoparticles showed superior cytotoxicity when compared to the free drug.
机译：该研究的目的是配制和评估基于白蛋白的纳米颗粒以递送5-氟尿嘧啶。通过凝聚法制备纳米颗粒。表征纳米颗粒的粒度，表面电荷，粒度分布和载药量。载药量从4.22％到19.8％（w / w）。平均粒径为141.9。 nm和表面电荷为-30.3。毫伏负载药物的颗粒表现出双相释放模式，具有初始爆发效应，随后在pH 7.4磷酸盐缓冲液中持续释放。药物释放是一阶扩散控制的，机理是菲克。与游离药物相比，载有药物的纳米颗粒显示出优异的细胞毒性。

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