Effect of a-crystallin on thermostability of mitochondrial aspartate aminotransferase

Kira A. Markossian; Nikolay V. Golub; Sergey Yu. Kleymenov; Konstantin O. Muranov; Mikhail V. Sholukh; Boris I. Kurganov

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Effect of a-crystallin on thermostability of mitochondrial aspartate aminotransferase

机译：a-结晶蛋白对线粒体天冬氨酸转氨酶热稳定性的影响

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Effect of a-crystallin on thermal inactivation, denaturation and aggregation of aspartate aminotransferase from pig heart mitochondria (mAAT) has been in the focus of this study. Acceleration of heat-induced inactivation of mAAT was demonstrated in the.presence of a-crystallin. According to the data of differential scanning calorimetry, α-crystallin induces destabilization of the mAAT molecule. The size of protein aggregates formed at heating of mAAT at a constant rate (1 °C/min) has been defined by dynamic light scattering. The obtained data show that aggregation of mAAT in the presence of a-crystallin proceeds in the regime of reaction-limited cluster-cluster aggregation.

机译：α-晶状体蛋白对猪心脏线粒体（mAAT）的天冬氨酸氨基转移酶的热失活，变性和聚集的影响一直是本研究的重点。 α-晶状体蛋白的存在证明了热诱导的mAAT失活的加速。根据差示扫描量热法的数据，α-晶状体蛋白诱导mAAT分子的不稳定。通过动态光散射确定了在以恒定速率（1°C / min）加热mAAT时形成的蛋白质聚集体的大小。所获得的数据表明，在α-晶状体蛋白存在下，mAAT的聚集以反应受限的簇-簇聚集的方式进行。

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《International Journal of Biological Macromolecules: Structure, Function and Interactions》 |2009年第5期|共6页
作者
Kira A. Markossian; Nikolay V. Golub; Sergey Yu. Kleymenov; Konstantin O. Muranov; Mikhail V. Sholukh; Boris I. Kurganov;
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正文语种 eng
中图分类 545LB053;
关键词
Mitochondrial aspartate aminotransferase; a-Crystallin; Aggregation;

机译：线粒体天冬氨酸转氨酶;α-晶体;聚集;

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1. Effect of a-crystallin on thermostability of mitochondrial aspartate aminotransferase [J] . Kira A. Markossian, Nikolay V. Golub, Sergey Yu. Kleymenov, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2009,第5期

机译：a-结晶蛋白对线粒体天冬氨酸转氨酶热稳定性的影响
2. Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV [J] . Han Q., Robinson H., Cai T., Bioscience Reports . 2011,第5期

机译：小鼠线粒体天冬氨酸转氨酶（一种新鉴定的犬尿氨酸转氨酶-IV）的生化和结构表征
3. Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV [J] . Danilo?A. Tagle, Howard Robinson, Jianyong Li, Bioscience Reports . 2011,第5期

机译：小鼠线粒体天冬氨酸转氨酶（一种新鉴定的犬尿氨酸转氨酶-IV）的生化和结构表征
4. Correlation Between Aspartate Aminotransferase/Alanine Transferase Ratio (AST/ALT Ratio) and Stage of Liver Fibrosis in Patients with Chronic Hepatitis [C] . Fitriani Lumongga, Radita Nur Anggraeni Public Health International Conference . 2017

机译：天冬氨酸氨基转移酶/丙氨酸转移酶比（AST / ALT比率）与慢性肝炎患者肝纤维化阶段的相关性
5. Aspartate aminotransferase and aromatic-amino-acid aminotransferase in Escherichia coli. [D] . Orr, Winson M. S. 1977

机译：大肠杆菌中的天冬氨酸转氨酶和芳香族氨基酸转氨酶。
6. Rapid Purification and Thermostability of the Cytoplasmic Aspartate Aminotransferase from Carrot Suspension Cultures [O] . Frank J. Turano, Barbara J. Wilson, Benjamin F. Matthews 1991

机译：胡萝卜悬浮培养物中细胞质天冬氨酸氨基转移酶的快速纯化和热稳定性
7. Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV [O] . Qian Han, Howard Robinson, Tao Cai, 2011

机译：小鼠线粒体天冬氨酸氨基转移酶的生化和结构表征，一种新鉴定的kynurenine氨基转移酶-4

Effect of a-crystallin on thermostability of mitochondrial aspartate aminotransferase

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