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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity
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Water-extracted polysaccharides from Azadirachta indica leaves: Structural features, chemical modification and anti-bovine herpesvirus type 1 (BoHV-1) activity

机译：印A（Azadirachta indica）叶片的水提取多糖：结构特征，化学修饰和抗牛疱疹病毒1型（BoHV-1）活性

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摘要

In this study, we have analyzed the pectic arabinogalactan isolated from Azadirachta indica and its chemically sulfated derivative. The native polysaccharide had an apparent molecular mass of 80. kDa and is made up of (1 → 5)-/(1 → 3,5)-linked α-l-arabinosyl, (1 → 3)-/(1 → 6)-/(1 → 3,6)-linked β-d-galactosyl, and terminal-rhamnosyl and α-l-arabinosyl residues. These macromolecules showed activity against bovine herpesvirus type-1. Their inhibitory concentration 50% values ranging from 31.12 to 105.25 μg/ml were lower than the cytotoxicity values (>1600-1440 μg/ml). The anti-viral effect was exerted during virus adsorption to the cell. Anionic groups in particular the sulfate groups appeared to be very important for the anti-herpetic activity of these polymers.
机译：在这项研究中，我们分析了从印度印苦za子中分离出的果胶阿拉伯半乳聚糖及其化学硫酸化衍生物。天然多糖的表观分子量为80. kDa，由（1→5）-/（1→3,5）连接的α-1-阿拉伯糖基，（1→3）-/（1→6）组成）-/（1→3,6）-连接的β-d-半乳糖基和末端鼠李糖基和α-1-阿拉伯糖基残基。这些大分子显示出抗1型牛疱疹病毒的活性。它们的抑制浓度50％值在31.12至105.25μg/ ml之间，低于细胞毒性值（> 1600-1440μg/ ml）。在病毒吸附到细胞的过程中发挥了抗病毒作用。阴离子基团，特别是硫酸根基团看来对于这些聚合物的抗疱疹活性非​​常重要。

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