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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering
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A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering

机译:用于骨组织工程的新型可注射温敏掺杂锌的壳聚糖/β-甘油磷酸水凝胶

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摘要

Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/β-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (β-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/β-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications.
机译:水凝胶是亲水性聚合物,具有广泛的生物医学应用,包括骨组织工程。在这项研究中,我们报告了一种用于骨骼组织工程的热敏水凝胶(Zn-CS /β-GP)的制备和表征,其中包含锌(Zn),壳聚糖(CS)和β-甘油磷酸酯(β-GP)。制备的水凝胶在室温下呈液态,在体温下变成凝胶。通过SEM,EDX,XRD,FT-IR和溶胀研究表征了水凝胶。水凝胶增强抗菌活性并促进成骨细胞分化。因此,我们认为Zn-CS /β-GP水凝胶作为骨组织工程应用的可注射原位形成支架可能具有潜在的影响。

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