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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >A novel three-dimensional tubular scaffold prepared from silk fibroin by electrospinning
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A novel three-dimensional tubular scaffold prepared from silk fibroin by electrospinning

机译：由丝素蛋白静电纺丝制备的新型三维管状支架

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摘要

Effects of electrospinning parameters (including voltage, collection distance, solution concentration and flow rate) on the morphology and diameter distribution of regenerated SF (silk fibroin) fiber were investigated. Afterward, SF tubular scaffold composed of homogenous fibers was fabricated at voltage of 18 collection distance of 18 cm, concentration of 37%, and flow rate of 0.15 mL/min. After methanol treatment, SF tubular scaffold showed tensile strength of 3.57 MPa and porosity of 80.85%. It is satisfied that work offers a simple method to fabricate seamless and porous tubular scaffold from SF without any additives and organic solvents. Furthermore, the results suggest that this tubular scaffold shows promising applications in small-diameter vascular graft.
机译：研究了电纺丝参数（包括电压，收集距离，溶液浓度和流速）对再生SF（丝素蛋白）纤维的形态和直径分布的影响。之后，以18个收集电压，18cm的收集电压，37％的浓度和0.15mL / min的流速制备由均质纤维组成的SF管状支架。经过甲醇处理后，SF管状支架的抗拉强度为3.57 MPa，孔隙率为80.85％。我们感到满意的是，这项工作提供了一种简单的方法，无需任何添加剂和有机溶剂即可从SF制造无缝且多孔的管状支架。此外，结果表明该管状支架在小直径血管移植物中显示出有希望的应用。

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