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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins
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The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins

机译：菊科精选药用植物中的多酚-多糖结合物对过氧亚硝酸盐诱导的血小板蛋白变化的影响

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Lots of plants belonging to Asteraceae family are very popular in folk medicine in Poland. These plants are also known as being rich in acidic polysaccharides, due to the presence of hexuronic acids or its derivatives. Our preliminary experiments have shown that the extract from Conyza canadensis L. possesses various biological activity, including antiplatelet, antiocoagulant and antioxidant properties. The aim of our study was to assess if macromolecular glycoconjugates from selected herbal plants of Asteraceae family: Achillea millefolium L., Arnica montana L., Echinacea purpurea L., Solidago virgaurea L., Chamomilla recutita (L.) Rauschert., and Conyza canadensis L. protect platelet proteins against nitrative and oxidative damage induced by peroxynitrite, which is responsible for oxidativeitrative modifications of platelet proteins: the formation of 3-nitrotyrosine and carbonyl groups. These modifications may lead to changes of blood platelet functions and can have pathological consequences. The role of these different medicinal plants in the defence against oxidativeitrative stress in human platelets is still unknown, therefore the oxidative damage to platelet proteins induced by peroxynitrite and protectory effects of tested conjugates by the estimation of carbonyl group level and nitrotyrosine formation (a marker of protein nitration) were studied in vitro. The antioxidative properties of the polyphenolic-polysaccharide conjugates from selected tested medicinal plants were also compared with the action of a well characterized antioxidative commercial polyphenol - resveratrol (3,4′,5-trihydroxystilbene). The obtained results demonstrate that the compounds from herbal plants: A. millefolium, A. montana, E. purpurea, C. recutita, S. virgaurea, possess antioxidative properties and protect platelet proteins against peroxynitrite toxicity in vitro, similar to the glycoconjugates from C. canadensis. However, in the comparative studies, the polyphenolic-polysaccharide conjugates from selected tested medicinal plants were not found to be more effective antioxidant, than the solution of pure resveratrol.
机译：在波兰，许多属于菊科的植物在民间医学中非常流行。由于己糖醛酸或其衍生物的存在，这些植物也被称为富含酸性多糖。我们的初步实验表明，加拿大Conyza canadensis L.的提取物具有多种生物活性，包括抗血小板，抗凝血和抗氧化性能。我们研究的目的是评估是否从菊科选择的草药植物中提取大分子糖缀合物：A草，山金车菊，紫锥菊，实心草，黄连，Chamomilla recutita（L.）Rauschert。和Conyza canadensis L.保护血小板蛋白质免受过氧亚硝酸盐引起的硝化和氧化损伤，过氧亚硝酸盐负责血小板蛋白质的氧化/硝化修饰：3-硝基酪氨酸和羰基的形成。这些修饰可能导致血小板功能改变，并可能导致病理后果。这些不同的药用植物在抵抗人类血小板氧化/硝化应激的作用中的作用仍是未知的，因此通过估计羰基水平和硝基酪氨酸的形成，过氧亚硝酸盐诱导的血小板蛋白的氧化损伤和测试的结合物的保护作用（a蛋白质硝化的标记）进行了体外研究。还比较了来自选定测试的药用植物的多酚-多糖共轭物的抗氧化特性，与特征明确的抗氧化商品多酚-白藜芦醇（3,4'，5-三羟基sti）的作用进行了比较。获得的结果表明，来自草药植物的化合物：A。millefolium，A。montana，E。purpurea，C。recutita，S。virgaurea，与C中的糖缀合物相似，在体外具有抗氧化特性并保护血小板蛋白免受过亚硝酸盐的毒性。加拿大一枝黄花然而，在比较研究中，没有发现来自选定测试的药用植物的多酚-多糖缀合物比纯白藜芦醇溶液更有效的抗氧化剂。

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