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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Alginate-based ferrofluid and magnetic microsphere thereof
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Alginate-based ferrofluid and magnetic microsphere thereof

机译：海藻酸盐基铁磁流体及其磁性微球

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The Fe_3O_4 ferrofluids have been prepared using sodium alginate (Na-AL) as a stabilizing agent. The alginate can prevent the aggregation of magnetic nanoparticles and hence contributed to higher stability for the ferrofluids. Furthermore, the alginate component in the ferrofluids was crosslinked by Ca~(2+) to produce magnetic microspheres. The swelling behavior of magnetic microspheres showed a pH-dependence, and hence determined the drug release process under various pH conditions. The presence of the Fe_3O_4 nanoparticles made the magnetic microspheres swell more easily. Meanwhile, the strong ability to absorb the drug for the incorporated Fe_3O_4 nanoparticles decreased the release rate and hence was more favorable to the sustaining release of drug. Except for the controlled delivery and release of drug, the alginate-based ferrofluids and magnetic microspheres in this work might also show a great potential for other biomedical and biotechnological applications, such as, magnetic targeting, magnetic separation and magnetic resonance imaging.
机译：已使用藻酸钠（Na-AL）作为稳定剂制备了Fe_3O_4铁磁流体。海藻酸盐可防止磁性纳米颗粒的聚集，因此有助于铁磁流体的更高稳定性。此外，铁磁流体中的藻酸盐成分通过Ca〜（2+）交联生成磁性微球。磁性微球的溶胀行为表现出pH依赖性，因此决定了在各种pH条件下的药物释放过程。 Fe_3O_4纳米粒子的存在使磁性微球更容易膨胀。同时，对于掺入的Fe_3O_4纳米颗粒的强吸收能力降低了释放速率，因此更有利于药物的持续释放。除药物的受控递送和释放外，这项工作中基于藻酸盐的铁磁流体和磁性微球还可能在其他生物医学和生物技术应用中显示出巨大潜力，例如磁性靶向，磁性分离和磁共振成像。

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