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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Calorimetric analysis of gelatine-glycosaminoglycans blend system
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Calorimetric analysis of gelatine-glycosaminoglycans blend system

机译：明胶-糖胺聚糖共混体系的量热分析

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摘要

Gelatine is one of the most valuable natural polymers used for drug delivery applications. Gelatine-GAGs based composite system has been shown to act as good scaffolds for tissue engineering. The objective of the present study is to investigate the calorimetric properties of microporous gelatine-GAGs based blend, which were modified by co-crosslinking with a naturally occurring crosslinking agent genipin. The melting temperature (T_m), enthalpy change (ΔH_m) and heat capacity change (ΔC_p) were systematically calculated over the experimentally observed systems using differential scanning calorimeter (DSC). The thermoporometry results suggest that the concentration of the glycosaminoglycans plays an important role in the pore size distribution of the blend matrices. The circular dichroism (CD) spectroscopy study, scanning electron microscopy (SEM) studies provide the valuable information about the structural features of the biodegradable blend that can be utilized for various biomedical applications. The results provide new insights into the thermal stability of blend and suggest potential strategies for its manipulation.
机译：明胶是用于药物递送应用的最有价值的天然聚合物之一。已证明基于明胶-GAGs的复合系统可作为组织工程的良好支架。本研究的目的是研究基于微孔明胶-GAGs的共混物的量热性质，该共混物通过与天然交联剂京尼平共交联而改性。使用差示扫描量热仪（DSC）在实验观察的系统上系统地计算了熔化温度（T_m），焓变（ΔH_m）和热容变化（ΔC_p）。热孔法结果表明，糖胺聚糖的浓度在混合基质的孔径分布中起重要作用。圆二色性（CD）光谱研究，扫描电子显微镜（SEM）研究提供了有关可生物降解混合物的结构特征的宝贵信息，这些可生物降解混合物可用于各种生物医学应用。结果为共混物的热稳定性提供了新的见解，并提出了潜在的混合策略。

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