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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >New versatile, elastomeric, degradable polymeric materials for medicine
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New versatile, elastomeric, degradable polymeric materials for medicine

机译：新型用途广泛的，可降解的弹性体高分子聚合物材料

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The present investigation was focused on the cell compatibility of recently developed biodegradable polyesterurethane-foam (DegraPol-foam) to chondrocytes and osteoblasts. Both chonorocytes and osteoblasts, isolated from adult male rats, exhibited relatively high cell adhesion on DegraPol-foam. Scanning electron microscopy (SEM) showed that cells grew on the surface and into the open cell pores of the foam. Morphologically, cells found on the surface of the foam exhibited a flat cell appearance and built a confluent cell multilayer. In contrast, inside the foams cell showed rounded morphology building cell aggregates and cell islets. In addition, chondrocytes and osteblasts proliferated on the DegraPol-foam and preserved their phenotype for up to 2 weeks. During degradation of these polymers, small crystalline particles of short-chain poly [(R)-3-hydroxybutyric acid] (M_n approx= 2300)(PHB-P) and lysine methyl ester are released. Therefore, lysine methyl ester and PHB-P, as possible degradation products of the polymer, are investigated here for their effects on macrophages and osteoblasts. Results obtained in the present study clearly indicate that macrophages and, to a lesser degree, osteoblasts have the ability to take up (phagocytose) PHB-P. At low concentrations, particles of PHB failed to induce cytotoxic effects or to activate macrophages. Osteoblasts showed only limited PHB-P phagocytosis and no signs of any cellular damage. At high concentrations of PHB-P, the cell viability of macrophages and to a lesser extent of osteoblasts was affected.
机译：目前的研究集中在最近开发的可生物降解的聚酯氨基甲酸酯泡沫（DegraPol-foam）与软骨细胞和成骨细胞的细胞相容性上。从成年雄性大鼠中分离出的软骨细胞和成骨细胞在DegraPol-泡沫上均表现出较高的细胞粘附性。扫描电子显微镜（SEM）显示，细胞在表面上生长并进入泡沫的开放孔中。形态上，在泡沫表面上发现的孔显示出平坦的孔外观，并形成了融合的孔多层。相反，在泡沫细胞内部显示出圆形的形态，从而形成细胞聚集体和细胞岛。此外，软骨细胞和成骨细胞在DegraPol泡沫中增殖，并保持其表型长达2周。在这些聚合物降解期间，释放了短链聚[（R）-3-羟基丁酸]（M_n大约= 2300）（PHB-P）和赖氨酸甲酯的小晶体颗粒。因此，在这里研究了赖氨酸甲酯和PHB-P，作为聚合物的可能降解产物，它们对巨噬细胞和成骨细胞的作用。在本研究中获得的结果清楚地表明，巨噬细胞和成骨细胞具有吸收（吞噬）PHB-P的能力。在低浓度下，PHB颗粒无法诱导细胞毒性作用或激活巨噬细胞。成骨细胞仅显示有限的PHB-P吞噬作用，没有任何细胞损伤的迹象。在高浓度的PHB-P下，巨噬细胞的细胞活力受到影响，成骨细胞的活力也受到影响。

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