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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >N-carboxyethyl chitosan fibers prepared as potential use in tissue engineering
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N-carboxyethyl chitosan fibers prepared as potential use in tissue engineering

机译：制备的N-羧乙基壳聚糖纤维可能在组织工程中使用

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摘要

To improve the hydrophilicity of chitosan fiber, N-carboxyethyl chitosan fiber was prepared through Michael addition between chitosan fiber with acrylic acid. The structure was studied by H-1 NMR. The degree of N-substitution, measured via H-1 NMR, was easily varied from 0.10 to 0.51 by varying the molar ratio of acrylic acid to chitosan. Series of properties of N-carboxyethyl chitosan fiber including mechanical property, crystallinity, thermal property and in vitro degradation were investigated by Instron machine, X-ray diffraction and differential scanning calorimetry and thermogravimetric analysis, respectively. The results showed that, introducing the carboxyethyl group into the backbone chain of chitosan fiber destroyed the intra/intermolecular hydrogen bonding, leading to loss of the intra/intermolecular hydrogen bonding and improvement of hydrophilicity. Indirect cytotoxicity assessment of carboxyethyl chitosan fibers was investigated using a L929 cell line. And the obtained results clearly suggested that N-carboxyethyl chitosan fiber was nontoxic to L929 cells. The N-carboxyethyl chitosan fibers are potential as tissue engineering scaffolds. (C) 2015 Elsevier B.V. All rights reserved.
机译：为了提高壳聚糖纤维的亲水性，通过在壳聚糖纤维与丙烯酸之间的迈克尔加成反应制备了N-羧乙基壳聚糖纤维。通过H-1 NMR研究结构。通过改变丙烯酸与壳聚糖的摩尔比，通过H-1 NMR测得的N-取代度很容易在0.10至0.51之间变化。利用Instron机器，X射线衍射，差示扫描量热法和热重分析法分别研究了N-羧乙基壳聚糖纤维的一系列机械性能，结晶度，热性能和体外降解性能。结果表明，将羧乙基引入壳聚糖纤维的主链中破坏了分子内/分子间的氢键，导致了分子内/分子间的氢键的丧失，提高了亲水性。使用L929细胞系研究了羧乙基壳聚糖纤维的间接细胞毒性评估。所得结果清楚地表明，N-羧乙基壳聚糖纤维对L929细胞无毒。 N-羧乙基壳聚糖纤维有可能作为组织工程支架。 （C）2015 Elsevier B.V.保留所有权利。

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