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Contribution of daily and seasonal biorhythms to obesity in humans

机译:每日和季节性生物节律对人类肥胖的贡献

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摘要

While the significance of obesity as a serious health problem is well recognized, little is known about whether and how biometerological factors and biorhythms causally contribute to obesity. Obesity is often associated with altered seasonal and daily rhythmicity in food intake, metabolism and adipose tissue function. Environmental stimuli affect both seasonal and daily rhythms, and the latter are under additional control of internal molecular oscillators, or body clocks. Modifications of clock genes in animals and changes to normal daily rhythms in humans (as in shift work and sleep deprivation) result in metabolic dysregulation that favours weight gain. Here, we briefly review the potential links between biorhythms and obesity in humans.
机译:尽管肥胖作为严重健康问题的重要性已得到公认,但对生物统计学因素和生物节律是否以及如何导致肥胖的原因知之甚少。肥胖通常与食物摄入,新陈代谢和脂肪组织功能的季节性和日常节律改变有关。环境刺激会影响季节性节律和日常节律,而节律则受内部分子振荡器或人体时钟的额外控制。动物中时钟基因的修饰和人类正常日常节奏的变化(如轮班工作和睡眠不足)会导致代谢失调,从而增加体重。在这里,我们简要回顾一下生物节律与人类肥胖之间的潜在联系。

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