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首页> 外文期刊>International Journal of Cancer =: Journal International du Cancer >Adiponectin is not effective against AOM-induced colon cancer but more evidence is required for its role in obesity-associated colon cancer: comment on the study by Ealey and Archer (2009).
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Adiponectin is not effective against AOM-induced colon cancer but more evidence is required for its role in obesity-associated colon cancer: comment on the study by Ealey and Archer (2009).

机译：脂联素不能有效对抗AOM引起的结肠癌，但需要更多的证据证明其在肥胖相关的结肠癌中的作用：Ealey and Archer（2009）对这项研究的评论。

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It is now well known that obesity increases the risk of colon cancer and the risk is correlated with increased body mass index. Increased blood levels of leptin, insulin, IGF-1, IL-6 and TNF-alpha in obesity are considered to promote the carcino-genesis through activation of several intracellular signal pathways, including PDK/Akt, MAPK and Stat3. Adiponectin counteracts these adverse effects, and thus decreased blood levels of adiponectin in obesity also contribute to the carcino-genesis of obesity-associated colon cancer. Knockout of the adiponectin gene and the adiponectin receptor genes 1 and 2 has been shown to accelerate azoxymethane (AOM)-induced colon cancer and this effect was alleviated by adiponectin supplement.We read with great interest the article by Ealey and Archer in your journal. To examine the role of adiponectin in the carcinogenesis of colon cancer, the authors developed mice with high levels of adiponectin expression and then fed them with a high-fat diet.
机译：现在众所周知，肥胖增加了结肠癌的风险，并且该风险与体重指数增加相关。肥胖中血液中瘦素，胰岛素，IGF-1，IL-6和TNF-α的水平升高被认为通过激活几种细胞内信号通路（包括PDK / Akt，MAPK和Stat3）来促进癌变。脂联素抵消了这些不利影响，因此，肥胖症中脂联素的血药浓度降低也有助于肥胖症相关结肠癌的癌变。脂联素基因和脂联素受体基因1和2的敲除已显示出可加速乙氧基甲烷（AOM）诱导的结肠癌，并且脂联素补充剂可减轻这种作用。我们非常感兴趣地阅读了Ealey和Archer的文章。为了研究脂联素在结肠癌致癌作用中的作用，作者开发了脂联素表达水平高的小鼠，然后给它们喂了高脂饮食。

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