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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) enriched hydrogels for transdermal delivery of flurbiprofen: formulation, in vitro characterisation, pharmacokinetic and pharmacodynamic studies in animals
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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) enriched hydrogels for transdermal delivery of flurbiprofen: formulation, in vitro characterisation, pharmacokinetic and pharmacodynamic studies in animals

机译：固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）富集的水凝胶用于氟比洛芬的透皮递送：动物制剂，体外表征，药代动力学和药效学研究

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摘要

Aqueous dispersions of flurbiprofen solid lipid nanoparticles (FLUSLN) and flurbiprofen nanostructured lipid carriers (FLUNLC) by hot homogenisation followed by sonication technique were prepared and then incorporated into the freshly prepared hydrogels for transdermal delivery. They are characterised for particle size, DSC, shape and surface morphology, in vitro drug release, rheological behaviour and in vivo studies. The pharmacokinetics of flurbiprofen in rats following application of SLN gel (A1) and NLC gel (Bl) for 24h were evaluated. The C_(max) of the NLC gel formulation was 38.67 +- 2.77 mug/ml, which was significantly higher than the SLN gel formulation (C_(max)= 21.79 +- 2.96 muug/ml). The bioavailability of flurbiprofen with reference to oral administration was found to increase by 4.4 times when gel formulations were applied. Anti-inflammatory effect in the carrageenan-induced paw edema in rat was significantly higher for NLC gel and SLN gel formulation than the orally administered flurbiprofen. Both the SLN and NLC dispersions and gels enriched with SLN and NLC possessed a sustained drug release over period of 24h.
机译：通过热均质然后超声处理，制备了氟比洛芬固体脂质纳米颗粒（FLUSLN）和氟比洛芬纳米结构脂质载体（FLUNLC）的水分散体，然后将其掺入新鲜制备的水凝胶中以进行透皮递送。它们的特征在于粒径，DSC，形状和表面形态，体外药物释放，流变行为和体内研究。评估了在应用SLN凝胶（A1）和NLC凝胶（B1）24h后氟比洛芬在大鼠体内的药代动力学。 NLC凝胶制剂的C_（max）为38.67±2.77马克杯/毫升，这显着高于SLN凝胶制剂（C_（max）＝ 21.79±2.96μug/ ml）。当施用凝胶制剂时，发现氟比洛芬相对于口服给药的生物利用度增加了4.4倍。 NLC凝胶和SLN凝胶制剂对角叉菜胶诱发的大鼠足水肿的抗炎作用明显高于口服氟比洛芬。 SLN和NLC分散液以及富含SLN和NLC的凝胶在24小时内均具有持续的药物释放。

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