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Bolaamphiphiles based novel liposomes: a possible approach for drug delivery

机译：基于Bolaamphiphiles的新型脂质体：一种可能的药物递送方法

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The present study was designed to develop a novel liposomal system containing dequalinium chloride (DEQ) as a charge-imparting constituent. Liposomes were prepared by cast film method with EPC: chol: DEQ molar ratio of 7:1:2. The novel liposomes were characterised for surface morphology, size and size distribution, entrapment efficiency and in vitro release study. Effect of osmotic shock was performed for establishment of liposomal bilayer stability and results demonstrated that incorporation of dequalinium chloride to the liposomal bilayer hindered the movement of entrapped solute. The hemolysis study was performed for estimation of its toxicological behaviour, if any. Cell-uptake studies showed that developed carrier could be useful for higher penetration in the cells compared to conventional liposomes. This being the first finding of its kind could open up a new era for the use of bolaamphiphiles like DEQ as an integral part of well established carrier like liposomes to provide them additional stability and efficacy.
机译：本研究的目的是开发一种新型的脂质体系统，其中含有氯化奎尔铵（DEQ）作为赋予电荷的成分。通过流延膜法制备脂质体，其中EPC∶chol∶DEQ摩尔比为7∶1∶2。对新型脂质体进行了表面形态，大小和大小分布，包封率和体外释放研究。进行渗透压休克的作用以建立脂质体双层稳定性，结果表明将氯喹qual铵掺入脂质体双层中会阻碍包埋的溶质的运动。进行溶血研究以评估其毒理学行为（如果有）。细胞摄取研究表明，与常规脂质体相比，开发的载体可用于更高的细胞渗透性。这是此类发现的首次发现，可以为使用诸如DEQ的双亲两性亲子作为成熟的载体（如脂质体）的组成部分提供新的时代，从而为它们提供额外的稳定性和功效。

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