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Potentiality of the plant Pseudotsuga menzietii to combat implant-related infection in the nanoregime

机译:植物假单胞菌(Pseudotsuga menzietii)对抗纳米系统中与植入物相关的感染的潜力

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摘要

Today, the most alarming problem in the biomedical arena is bacterial infection at the site of implanted medical devices, prosthetics and sensors. Despite aseptic measures and sterilisation procedures microbial infection poses a major impediment and a big question mark to the utility of biomaterials. Therefore, in this nanoregime, we have attempted to bring forth antimicrobial, self-sterilising silver/chitosan bionanocomposite which can indubitably be used for coating of medical implants and surgical devices. Herbal route employing leaves of the plant Pseudotsuga menzietii, the Christmas tree, has been implicated for the formation of silver nanoparticles. For the first time, this plant has been involved for the biosynthesis of nanoparticles and to mitigate the menace of implant associated infection. To investigate the formation of silver nanoparticles and the development of bionanocomposite, several characterisation techniques have been used like UV/visible spectroscopy, transmission electron microscopy, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, FT-IR spectroscopy, etc. together with antimicrobial analysis. Thus, in a cost effective way we have strived to develop a winning strategy to conquer implant-related infection.
机译:如今,生物医学领域中最令人担忧的问题是植入的医疗设备,假肢和传感器部位的细菌感染。尽管采取了无菌措施和灭菌程序,微生物感染还是对生物材料实用性的主要障碍和重大问号。因此,在这种纳米体系中,我们试图提出一种抗菌的,自灭菌的银/壳聚糖生物纳米复合材料,可以毫无疑问地用于医疗植入物和外科手术器械的涂层。使用植物假单胞菌(Pseudotsuga menzietii)的叶子(圣诞树)的草药路线与银纳米颗粒的形成有关。该植物首次参与了纳米颗粒的生物合成并减轻了植入相关感染的威胁。为了研究银纳米颗粒的形成和生物纳米复合材料的发展,已经使用了几种表征技术,例如紫外/可见光谱,透射电子显微镜,扫描电子显微镜,X射线衍射,差示扫描量热法,FT-IR光谱等。进行抗菌分析。因此,我们以一种经济有效的方式努力开发出一种成功的策略来克服植入物相关的感染。

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