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首页> 外文期刊>International Journal of Cancer =: Journal International du Cancer >The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women.
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The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women.

机译：绝经后妇女血浆雄激素水平与乳腺癌，卵巢癌和子宫内膜癌的危险因素相关。

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摘要

Although androgens may play an etiologic role in breast, ovarian and endometrial cancers, little is known about factors that influence circulating androgen levels. We conducted a cross-sectional analysis among 646 postmenopausal women in the Nurses' Health Study to examine associations between adult risk factors for cancer, including the Rosner/Colditz breast cancer risk score, and plasma levels of testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). All analyses were adjusted for age, laboratory batch and other cancer risk factors. Free testosterone levels were 79% higher among women with a body mass index of > or =30 vs. <22 kg/m(2) (p-trend <0.01) and 25% higher among women with a waist circumference of >89 vs. < or =74 cm (p-trend = 0.02). Consuming >30 g of alcohol a day vs. none was associated with a 31% increase in DHEA and 59% increase in DHEAS levels (p-trend = 0.01 and <0.01, respectively). Smokers of > or =25 cigarettes per day had 35% higher androstenedione and 44% higher testosterone levels than never smokers (p-value, F-test = 0.03 and 0.01, respectively). No significant associations were observed for height or time since menopause with any androgen. Testosterone and free testosterone levels were approximately 30% lower among women with a hysterectomy vs. without (both p-values < 0.01). Overall breast cancer risk was not associated with any of the androgens. Thus, several risk factors, including body size, alcohol intake, smoking and hysterectomy, were related to androgen levels among postmenopausal women, while others, including height and time since menopause, were not. Future studies are needed to clarify further which lifestyle factors modulate androgen levels.
机译：尽管雄激素可能在乳腺癌，卵巢癌和子宫内膜癌中起病因作用，但对影响循环雄激素水平的因素知之甚少。我们在《护士健康研究》中对646名绝经后妇女进行了横断面分析，以检查成人癌症风险因素（包括Rosner / Colditz乳腺癌风险评分）与血浆睾丸激素，游离睾丸激素，雄烯二酮，脱氢表雄酮（ DHEA）和硫酸DHEA（DHEAS）。所有分析均根据年龄，实验室批次和其他癌症危险因素进行了调整。体重指数>或= 30 vs. <22 kg / m（2）的女性中游离睾丸激素水平高79％，腰围> 89的女性中游离睾丸激素水平高25％。 <或= 74厘米（p趋势= 0.02）。每天摄入30克以上的酒精而不摄入酒精，与DHEA的31％升高和DHEAS的59％升高相关（p趋势分别为0.01和<0.01）。每天吸烟≥25支的吸烟者的雄烯二酮水平和睾丸激素水平比从不吸烟者高35％（p值，F检验分别为0.03和0.01）。自绝经与任何雄激素接触以来，未观察到身高或时间的显着关联。子宫切除术妇女的睾丸激素和游离睾丸激素水平比没有子宫切除术的妇女低（两者p值均<0.01）。总体乳腺癌风险与任何雄激素都不相关。因此，绝经后女性中雄激素水平与身体大小，饮酒，吸烟和子宫切除等一些危险因素有关，而绝经后的身高和时间则与其他危险因素无关。需要进一步的研究来进一步阐明哪些生活方式因素调节雄激素水平。

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