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首页> 外文期刊>International Journal of Biomedical Science >A Comparative Study of Serum Uric Acid levels and Lipid Ratios in Coronary Artery Disease Patients
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A Comparative Study of Serum Uric Acid levels and Lipid Ratios in Coronary Artery Disease Patients

机译:冠心病患者血尿酸水平和血脂比的比较研究

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Introduction: Coronary Artery Disease (CAD) appears to be common in the Indian population of different geographical origins, religions and languages. Measurement of lipid fractions and ratios are widely recommended for risk assessment. A few studies have shown that serum uric acid plays a role in the development of cardiovascular morbidity. Very few reports are cited linking serum uric acid with the lipid fraction in CAD. Objectives: To find the significance of non-HDL cholesterol, LDL-c/HDL-c ratio, TC/HDL ratio and serum uric acid level in CAD patients. Subjects and Methodology: In this study, we included fifty CAD patients as subjects and an equal number of controls. Both subjects and controls were assessed for anthropometric, physiological and biochemical parameters. Results: The present study showed significant increased levels of total cholesterol (p=0.002), TAGs (p<0.001), HDL (p=0.005), LDL (p<0.006) and non-HDL cholesterol (p<0.001). LDL-c/HDL-c ratio (p<0.001) and TC/HDL ratio (p<0.001) in CAD patients (subjects) were also significant when compared to controls. Uric acid level in CAD patients was increased (p<0.001). Conclusion: Serum Uric Acid, TC/HDL and LDL/HDL ratios could be regarded as objective markers, in association with existing atherogenic dyslipidemia in patients with CAD.
机译:简介:在不同地理起源,宗教和语言的印度人口中,冠状动脉疾病(CAD)似乎很常见。广泛建议测量脂质分数和比率以进行风险评估。一些研究表明,血清尿酸在心血管疾病的发生中起作用。很少有报道将血清尿酸与CAD中的脂质成分联系起来。目的:探讨非HDL胆固醇,LDL-c / HDL-c比,TC / HDL比和CAD患者血清尿酸水平的意义。受试者和方法:在这项研究中,我们纳入了50名CAD患者作为受试者,并采用了相同数量的对照。评估受试者和对照的人体测量学,生理和生化参数。结果:本研究显示总胆固醇(p = 0.002),TAGs(p <0.001),HDL(p = 0.005),LDL(p <0.006)和非HDL胆固醇(p <0.001)显着增加。与对照组相比,CAD患者(受试者)的LDL-c / HDL-c比(p <0.001)和TC / HDL比(p <0.001)也很显着。 CAD患者的尿酸水平升高(p <0.001)。结论:血清尿酸,TC / HDL和LDL / HDL比值可作为客观标志物,并与CAD患者现有的动脉粥样硬化血脂异常相关。

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