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首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Comparison of caudal tramadol vs bupivacaine for post-operative analgesia in children undergoing hypospadias surgery.
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Comparison of caudal tramadol vs bupivacaine for post-operative analgesia in children undergoing hypospadias surgery.

机译：尿道下裂手术患儿术后使用镇痛曲马多和布比卡因的比较。

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In a prospective double-blind study, 40 children scheduled for hypospadias repair were allocated randomly to receive either caudal tramadol (1 mg/kg) or 0.25% plain bupivacaine (0.5 ml/kg). Postoperative pain score, side-effects and oxygen saturation (SaO2) were recorded during 24-hour observation period. The results point toward a significantly lower pain scores with caudal bupivacaine in the immediate postoperative period, whereas caudal tramadol caused a significantly lower pain score in the late postoperative period. Total consumption of rescue analgesics was significantly higher in bupivacaine group as compared to tramadol group during the study period (p < 0.001). The incidence of side-effects such as vomiting was more frequent with caudal tramadol, but there was no detectable difference in SaO2. We conclude that caudal tramadol can safely be used for postoperative analgesia with a longer duration as compared to caudal bupivacaine.
机译：在一项前瞻性双盲研究中，随机分配了40名计划进行尿道下裂修复的儿童接受尾曲马多（1 mg / kg）或0.25％普通布比卡因（0.5 ml / kg）。在24小时观察期内记录术后疼痛评分，副作用和血氧饱和度（SaO2）。结果表明，术后不久，布比卡因尾部疼痛评分明显降低，而曲马多的尾部在术后后期疼痛评分显着降低。在研究期间，布比卡因组的抢救性镇痛剂总消耗量比曲马多组高得多（p <0.001）。尾曲马多的呕吐等副作用的发生率更高，但SaO2的差异无可检测到。我们得出的结论是，与尾部布比卡因相比，尾部曲马多可以安全地用于术后镇痛，持续时间更长。

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