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首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension.
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Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension.

机译：苯那普利-氨氯地平和卡托普利-噻嗪类药物组合治疗轻度至中度高血压的比较。

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OBJECTIVE: To compare the efficacy and tolerability of benazepril 10 mg + amlodipine 5 mg combination (BZ+AM) versus captopril 50 mg + hydrochlorothiazide 25 mg (CP+HT) combination. MATERIAL: 405 outpatients with mild-to-moderate arterial hypertension not adequately controlled by a monotherapy with ACE inhibitors or calcium channel blockers or diuretics entered this multicenter, double-blind, randomized, parallel-group study. METHOD: After a 2-week placebo run-in, 397 patients with sitting diastolic (D) blood pressure (BP) > 95 mmHg and/or sitting systolic (S) BP > 160 mmHg were randomized to receive either BZ+AM (201 patients) or CP+HT (196 patients) once daily for 12 weeks. Main outcome measure was sitting DBP and SBP values at the end of active treatment. The response rate was defined as the proportion of patients with either a final sitting DBP < 90 mmHg or decreased by at least 10 mmHg or a sitting SBP < 150 mmHg or decreased by at least 20 mmHg from baseline. RESULTS: The DBP and SBP values obtained with BZ+AM were, respectively, 2.7 and 3.7 mmHg lower than those obtained with CP+HT (both p < 0.001 vs. CP+HT). The response rate in the BZ+AM group (94.8%) was better than that observed in the CP+HT group (86.0%, p = 0.004). The incidence of adverse events was similar with the 2 treatment regimens (17.9% for both). CONCLUSIONS: These data suggest a higher antihypertensive efficacy of the fixed combination BZ 10 mg+AM 5 mg as compared with CP 50 mg+HT 25 mg.
机译：目的：比较苯那普利10 mg +氨氯地平5 mg组合（BZ + AM）与卡托普利50 mg +氢氯噻嗪25 mg（CP + HT）组合的疗效和耐受性。材料：405例轻度至中度动脉高血压患者未通过使用ACE抑制剂或钙通道阻滞剂或利尿剂的单药治疗得到充分控制，因此参加了这项多中心，双盲，随机，平行分组研究。方法：在进行了2周的安慰剂磨合后，将397例坐位舒张压（D）血压（BP）> 95 mmHg和/或坐位收缩压（S）BP> 160 mmHg的患者随机分为BZ + AM组（201 ）或CP + HT（196例），每天一次，持续12周。主要结局指标是积极治疗结束时的坐位DBP和SBP值。缓解率定义为最终坐位DBP <90 mmHg或降低至少10 mmHg或坐位SBP <150 mmHg或降低基线至少20 mmHg的患者比例。结果：BZ + AM所获得的DBP和SBP值分别比CP + HT所获得的DBP和SBP值分别低2.7和3.7 mmHg（p <0.001，而CP + HT两者）。 BZ + AM组的有效率（94.8％）优于CP + HT组的有效率（86.0％，p = 0.004）。不良事件的发生率与两种治疗方案相似（两种方法均占17.9％）。结论：这些数据表明固定组合BZ 10 mg + AM 5 mg的抗高血压功效高于CP 50 mg + HT 25 mg。

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