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首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Anthropometric data and acetylsalicylic acid pharmacokinetics.
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Anthropometric data and acetylsalicylic acid pharmacokinetics.

机译：人体测量数据和乙酰水杨酸药代动力学。

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摘要

The relationship between anthropometric data and pharmacokinetic characteristics of acetylsalicylic acid (ASA) after administration of a single oral dose of 500 mg ASA, an oral and intravenous dose of 500 mg D,L-lysine-mono-acetylsalicylate (Lys-ASA) and an oral dose of 1,000 mg Lys-ASA were evaluated. Individual data from an open, randomized crossover trial in 13 healthy volunteers (age 18-50 years, 6 female, 7 male, height 158-189 cm, weight 45-118 kg) were re-analyzed using a non-compartmental approach. The influence of body weight, height, body surface area and age on pharmacokinetic characteristics (Cmax, Tmax, AUClast, MRTlast, t 1/2, Cl, Vd) was assessed using the multiple regression method and pairwise multiple correlations were calculated. Multiple regression analysis showed significant multiple correlation coefficients of approximately 0.86 for Cmax (500 mg Lys-ASA i.v., 1,000 mg Lys-ASA per os and 500 mg ASA per os), Cl and AUClast (1,000 mg Lys-ASA per os). Standardized regression values (beta) reflected a major contribution for height, weight and body surface area, but age was not a relevant factor. Pairwise comparisons confirmed negative correlations between anthropometric characteristics and Cmax, AUClast and MRTlast and positive correlations between anthropometric data, Cl and Vd. In conclusion, apart from Tmax and t 1/2, all pharmacokinetic characteristics were influenced by body weight, height and body surface area. Whereas repeated administration of high doses in patients with low body weights may give rise to toxic effects, acute single dose administration would not lead to significant under-dosing in tall or stout patients.
机译：单次口服剂量500 mg ASA，口服和静脉内剂量500 mg D，L-赖氨酸-单乙酰水杨酸酯（Lys-ASA）和评估了1,000 mg Lys-ASA的口服剂量。使用非房室方法对来自13位健康志愿者（年龄18至50岁，女性6位，男性7位，身高158-189厘米，体重45-118公斤）的开放，随机交叉试验的个体数据进行了重新分析。使用多元回归方法评估体重，身高，体表面积和年龄对药代动力学特征（Cmax，Tmax，AUClast，MRTlast，t 1/2，Cl，Vd）的影响，并计算成对的多重相关性。多元回归分析显示，Cmax（500 mg Lys-ASA i.v.，1,000 mg Lys-ASA / os和500 mg ASA / os），Cl和AUClast（1,000 mg Lys-ASA / os）的显着多重相关系数约为0.86。标准化回归值（β）反映出身高，体重和体表面积的主要贡献，但年龄并不是一个相关因素。成对比较证实了人体测量特征与Cmax，AUClast和MRTlast之间的负相关以及人体测量数据Cl和Vd之间的正相关。总之，除Tmax和t 1/2外，所有药代动力学特征均受体重，身高和体表面积的影响。低体重患者反复高剂量服用可能会产生毒性作用，而急性高剂量单剂量服用不会导致身高或粗壮患者出现明显的剂量不足。

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