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首页> 外文期刊>International journal of clinical rheumatology. >CD4~+ T-cell subsets in rheumatoid arthritis
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CD4~+ T-cell subsets in rheumatoid arthritis

机译：类风湿关节炎的CD4〜+ T细胞亚群

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摘要

The exact pathogenesis of rheumatoid arthritis (RA) remains uncertain, however, autoimmune processes appear critical. In the past decades, several models implicated T cells at different levels; however, recent genetic advances have clearly indicated a role for T cells, maybe somehow limited to autoantibody positive disease. Processes involved in aging seem to occur early in RA and deviation from normal physiological pathways such as repertoire diversification, signaling, differentiation, polarisation or regulation also characterized T cells from RA patients. Despite such evidence, T-cell targeted therapies did not appear to be particularly successful with the exception of costimulation blockade, the reasons for this failure remaining unclear. Importantly, T-cell subsets demonstrated interesting biomarker features that remain to be investigated in relation with early diagnostic, prognostic and prediction of treatment response.
机译：类风湿关节炎（RA）的确切发病机理仍不确定，但是，自身免疫过程显得至关重要。在过去的几十年中，几种模型涉及不同水平的T细胞。然而，最近的遗传学进展清楚地表明了T细胞的作用，也许某种程度上仅限于自身抗体阳性疾病。与衰老有关的过程似乎发生在RA的早期，并且偏离正常的生理途径，例如库的多样化，信号传导，分化，极化或调节，也表征了RA患者的T细胞。尽管有这样的证据，但T细胞靶向疗法似乎没有特别成功，除了协同刺激被阻断外，这种失败的原因尚不清楚。重要的是，T细胞亚群表现出有趣的生物标志物功能，与早期诊断，预后和治疗反应预测有关，还有待研究。

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