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首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Effect of ulinastatin on serum inflammatory factors in Asian patients with acute pancreatitis before and after treatment: a meta-analysis
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Effect of ulinastatin on serum inflammatory factors in Asian patients with acute pancreatitis before and after treatment: a meta-analysis

机译：乌司他丁对亚洲急性胰腺炎患者治疗前后血清炎性因子的影响：荟萃分析

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Objective: We applied a meta analysis to explore the effect of ulinastatin (UTI) on the serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) in Asian patients with acute pancreatitis (AP). Methods: Various databases were searched based on stringent inclusion and exclusion criteria to extract relevant cohort studies. Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA) was applied for statistical analyses. Results: A total of 113 relevant studies (67 in Chinese, 46 in English) were initially retrieved. Finally, 11 eligible studies were enrolled in our meta-analysis with 399 pancreatitis patients. Meta-analysis results showed that after being treated with UTI, the serum levels of CRP, IL-6, and TNF-alpha were evidently decreased (CRP: SMD = -2.697, 95% CI = -4.399 similar to -0.994, p = 0.002; IL-6: SMD = -5.268, 95% CI = -9.850 similar to -0.687, p = 0.024; TNF-alpha: SMD = -5.666, 95% CI = -11.083 similar to -0.249, p = 0.040). Conclusion: UTI can effectively reduce the serum levels of CRP, IL-6, and TNF-alpha in Asian patients with AP, suggesting that UTI has anti-inflammatory effect on Asian patients with AP.
机译：目的：我们进行了荟萃分析，以探讨乌司他丁（UTI）对亚洲患者血清C反应蛋白（CRP），白介素6（IL-6）和肿瘤坏死因子α（TNF-alpha）的影响患有急性胰腺炎（AP）。方法：根据严格的纳入和排除标准搜索各种数据库，以提取相关的队列研究。综合Meta分析2.0（Biostat Inc.，Englewood，NJ，美国）用于统计分析。结果：最初检索到113篇相关研究（中文67篇，英文46篇）。最后，我们对399例胰腺炎患者进行了11项合格的研究纳入荟萃分析。荟萃分析结果显示，用UTI治疗后，血清CRP，IL-6和TNF-α水平明显降低（CRP：SMD = -2.697，95％CI = -4.399，与-0.994相似，p = 0.002; IL-6：SMD = -5.268，95％CI = -9.850类似于-0.687，p = 0.024; TNF-alpha：SMD = -5.666，95％CI = -11.083类似于-0.249，p = 0.040） 。结论：尿路感染可有效降低亚洲AP患者的血清CRP，IL-6和TNF-α水平，提示尿路感染对亚洲AP患者具有抗炎作用。

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