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首页> 外文期刊>International journal of clinical rheumatology. >Gene-gene interactions of HLA-B27 and ERAP1 in ankylosing spondylitis: Finding the pieces of the puzzle
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Gene-gene interactions of HLA-B27 and ERAP1 in ankylosing spondylitis: Finding the pieces of the puzzle

机译：HLA-B27和ERAP1在强直性脊柱炎中的基因-基因相互作用：发现难题

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摘要

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease of unknown etiology with a strong genetic susceptibility. Significant progress is being made in our understanding of the pathogenetic mechanisms involved in this disease, and the recent genome-wide association study (GWAS) results have linked at least 60 loci to AS [1]. Although GWAS has yielded remarkable results in associating different genetic polymorphism to AS susceptibility, many of these candidate genes have not been well characterized. However, these studies have revealed some important biologic pathways that may be involved in etiopathogenesis of AS [1,2].
机译：强直性脊柱炎（AS）是一种病因不明的慢性炎性风湿病，具有很强的遗传易感性。我们对这种疾病的致病机理的了解正在取得重大进展，并且最近的全基因组关联研究（GWAS）结果已将至少60个基因座与AS相关[1]。尽管GWAS在将不同的遗传多态性与AS易感性相关联方面取得了显著成果，但其中许多候选基因尚未得到很好的表征。然而，这些研究已经揭示了一些重要的生物学途径，可能与AS的发病机制有关[1,2]。

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