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首页> 外文期刊>International journal of clinical rheumatology. >Combination antibiotics for the treatment of Chlamydia-induced reactive arthritis: Is a cure in sight?
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Combination antibiotics for the treatment of Chlamydia-induced reactive arthritis: Is a cure in sight?

机译：联合用抗生素治疗衣原体诱发的反应性关节炎：有没有治愈的方法？

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摘要

The inflammatory arthritis that develops in some patients subsequent to urogenital infection by the obligate intracellular bacterial pathogen Chlamydia trachomatis, and that induced subsequent to pulmonary infection with C. pneumoniae, both have proved difficult to treat in either their acute or chronic forms. Over the last two decades, molecular genetic and other studies of these pathogens have provided a good deal of information regarding their metabolic and genetic structures, as well as the detailed means by which they interact with their host cells. In turn, these insights have provided for the first time a window into the bases for treatment failures for the inflammatory arthritis. In this article we discuss the biological bases for those treatment failures, provide suggestions as to research directions that should allow improvement in treatment modalities, and speculate on how treatment regimens that currently show promise might be significantly improved over the near future using nanotechological means.
机译：在某些患者中，专性细胞内细菌病原体沙眼衣原体感染在泌尿生殖系统感染后发展为炎症性关节炎，肺炎衣原体肺感染之后诱发的炎症性关节炎已被证明很难以其急性或慢性形式治疗。在过去的二十年中，对这些病原体的分子遗传学和其他研究提供了有关其代谢和遗传结构以及它们与宿主细胞相互作用的详细方法的大量信息。反过来，这些见解首次为炎症性关节炎治疗失败的基础提供了一个窗口。在本文中，我们讨论了导致这些治疗失败的生物学基础，为应该允许改善治疗方式的研究方向提供了建议，并推测了当前显示出希望的治疗方案在不久的将来可以使用纳米技术手段得到显着改善。

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