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首页> 外文期刊>International journal of clinical rheumatology. >Targeting the time of day for glucocorticoid delivery in rheumatoid arthritis
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Targeting the time of day for glucocorticoid delivery in rheumatoid arthritis

机译：定位类风湿关节炎中糖皮质激素的递送时间

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Glucocorticoid treatment for rheumatoid arthritis is generally taken in the mornings, and there is some evidence to support this practice. However, increased understanding of the role of cytokines in the pathogenesis of rheumatoid arthritis, and of their interaction with the hypothalamic-pituitary- adrenal axis, has suggested that glucocorticoids delivered in the early hours of the morning may have additional efficacy. The development of appropriate tablet technology and the conduct of randomized controlled trials and detailed clinical studies have shown that the early morning increase in plasma IL-6 concentrations, and its associated diurnal increase in symptoms such as morning stiffness can both be reduced by nocturnal glucocorticoid treatment. Fears that hypothalamic-pituitary-adrenal axis responses might be further blunted appear to be unfounded.
机译：类风湿关节炎的糖皮质激素治疗通常在早晨进行，并且有一些证据支持这种做法。然而，对细胞因子在类风湿关节炎发病机理中的作用及其与下丘脑-垂体-肾上腺轴相互作用的认识的增加，表明在清晨递送的糖皮质激素可能具有额外的疗效。适当的片剂技术的发展以及进行的随机对照试验和详细的临床研究表明，夜间糖皮质激素治疗可同时降低血浆IL-6浓度的清晨升高及其相关的昼夜症状如晨僵。下丘脑-垂体-肾上腺轴反应可能进一步减弱的恐惧似乎没有根据。

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