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首页> 外文期刊>International journal of colorectal disease. >p53 protein accumulation as a prognostic marker in sporadic colorectal cancer.
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p53 protein accumulation as a prognostic marker in sporadic colorectal cancer.

机译：p53蛋白积聚是散发性结直肠癌的预后标志物。

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BACKGROUND AND AIMS: p53 protein plays a crucial role in the pathogenesis of a large number of malignancies. In this study, our goal was to elucidate the prognostic role of p53 overexpression and its relationship to clinicopathological variables in colorectal cancer. MATERIALS AND METHODS: Between 1999 and 2004, surgical specimens of 258 patients who received surgical treatment for colorectal cancer at the Veterans General Hospital, Taipei were collected. p53 expression in tumor tissue was evaluated by immunohistochemical analysis using the human p53-specific mouse monoclonal antibody, PAb 1801. RESULTS: Of the 258 patients, 97 (37.6%) had overexpression of p53 in tumor tissues. The accumulation of p53 protein in tumor tissues did not correlate with age, gender, preoperative serum carcinoembryonic antigen (CEA) level, mucin content, nodal status, and tumor stage. A statistically significant correlation was found between p53 overexpression and location of the tumor in the rectum (p=0.038). Well to moderately differentiated tumors had significantly higher frequency of p53 overexpression than poorly differentiated tumors (40.0 vs 20.0%, p=0.050). Each patient was followed up for a minimum of 2 years (median 35 months). In univariate analysis, 3-year cancer-specific survival rate was significantly higher in patients with tumor p53 overexpression (88.2%) than in patients without overexpression (log rank test, p=0.037). However, in multivariate analysis, the tumour node metastasis stage remained the most significant independent prognostic factor. CONCLUSION: The accumulation of p53 protein might have a favorable prognostic value in colorectal cancer, but it is not an independent prognostic factor.
机译：背景与目的：p53蛋白在大量恶性肿瘤的发病机理中起着至关重要的作用。在这项研究中，我们的目标是阐明p53过表达的预后作用及其与大肠癌临床病理变量的关系。材料与方法：在1999年至2004年之间，收集了台北退伍军人总医院接受大肠癌手术治疗的258例患者的手术标本。使用人p53特异性小鼠单克隆抗体PAb 1801通过免疫组织化学分析评估了肿瘤组织中p53的表达。结果：在258例患者中，有97例（37.6％）在肿瘤组织中过表达p53。 p53蛋白在肿瘤组织中的积累与年龄，性别，术前血清癌胚抗原（CEA）水平，粘蛋白含量，淋巴结状态和肿瘤分期无关。发现p53过表达与肿瘤在直肠中的位置之间存在统计学上的显着相关性（p = 0.038）。高分化至中分化的肿瘤的p53过度表达的频率明显高于低分化分化的肿瘤（40.0 vs 20.0％，p = 0.050）。每位患者至少随访2年（中位数35个月）。在单变量分析中，肿瘤p53过度表达的患者的3年癌症特异性生存率显着高于没有过度表达的患者（对数秩检验，p = 0.037）（88.2％）。然而，在多变量分析中，肿瘤结节转移阶段仍是最重要的独立预后因素。结论：p53蛋白的积累在结直肠癌中可能具有良好的预后价值，但并不是独立的预后因素。

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