...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of colorectal disease. >The survival rate and prognostic factors in 26 perforated colorectal cancer patients.
【24h】

The survival rate and prognostic factors in 26 perforated colorectal cancer patients.

机译：26例穿孔结直肠癌患者的生存率和预后因素。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: The treatment for perforated colorectal cancer is not easy and the prognosis for this disease is not so predictable. There are some controversies about performing radical operations because colorectal cancer perforation was considered as an advanced stage disease due to the possibility of tumor cell dissemination through the perforation site. METHODS: We selected and enrolled 26 patients with perforated colorectal cancers among the 1,227 patients who underwent operation for colorectal cancer. These cases were retrospectively analyzed by using their medical records and clinicopathological data. RESULTS: Twenty-eight cases (2.3%) with perforated colorectal cancers were studied and the overall operative mortality rate was 11%. The overall 5-year survival rate was 57.8% when excluding the operative mortality. The overall 5-year cancer-free survival rate was 52.8%. There were significant differences in the survival rate and the cancer-free survival rate between the stages (p=0.008 and p<0.001, respectively). A univariate analysis of the prognostic factors revealed that the number of the metastatic lymph nodes (p=0.018) and the perforation proximal to the cancer (p=0.005) were significantly correlated to worse survival, and the higher number of the metastatic lymph nodes was correlated to a poorer cancer-free survival rate (p<0.001). CONCLUSION: For the perforated colorectal cancers, the stage, the perforation proximal to the cancer, and the number of the metastatic lymph nodes were correlated, with the survival and the cancer-free survival as factors of a poor prognosis. The surgical approach selected for perforated colorectal cancer should be in line with the principles of an appropriate cancer operation because the clinical pathway of perforated colorectal cancer is similar to that of uncomplicated colorectal cancer.
机译：目的：穿孔性大肠癌的治疗并不容易，这种疾病的预后也不太可预测。关于进行根治性手术存在一些争议，因为由于肿瘤细胞可能会通过穿孔部位扩散，因此结肠直肠癌穿孔被认为是晚期疾病。方法：我们在1,227名接受结直肠癌手术的患者中选择并招募了26例穿孔性结直肠癌患者。使用他们的病历和临床病理资料对这些病例进行回顾性分析。结果：研究了28例（2.3％）穿孔性大肠癌，总手术死亡率为11％。若不计手术死亡率，则5年总生存率为57.8％。总体5年无癌生存率为52.8％。在各阶段之间，生存率和无癌生存率存在显着差异（分别为p = 0.008和p <0.001）。对预后因素的单因素分析显示，转移性淋巴结的数目（p = 0.018）和癌旁穿孔（p = 0.005）与生存期差显着相关，转移性淋巴结数目更多与较差的无癌生存率相关（p <0.001）。结论：对于穿孔性大肠癌，其分期，癌旁穿孔和转移性淋巴结数目与预后不良的生存率和无癌生存率相关。为穿孔性结直肠癌选择的手术方法应符合适当的癌症手术原则，因为穿孔性结直肠癌的临床途径与简单的结直肠癌相似。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号