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首页> 外文期刊>International journal of colorectal disease. >E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer: A meta-analysis
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E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer: A meta-analysis

机译：E-钙粘蛋白（CDH1）基因启动子多态性与大肠癌的风险：荟萃分析

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Objective Published data on the relationship between E-cadherin (CDH1) gene promoter polymorphisms and colorectal cancer (CRC) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was carried out. Methods: In this meta-analysis, we evaluated reported studies of associations between polymorphisms of CDH1 gene promoter ?160 C>A and ?347 G>GA site, and CRC risk using fixed-effects model and random-effects model. Results: We found decreased CRC risk among subjects carrying CDH1 ?160AA (odds ratio [OR]=0.86, 95 percent confidence interval [95% CI]: 0.75-0.98) and CA+AA (OR=0.92, 95% CI: 0.87-0.98), using 4, 652/4, 428 cases/controls and 7, 866/7, 689 cases/controls from ten studies, respectively. We found a protective effect of the CDH1 ?160CA+AA polymorphisms for CRC in distal site tumor population and population-based control in stratified analysis. We found a protective effect of the CDH1 ?160AA and CA+AA polymorphisms for CRC in European and American population (OR=0.87, 95% CI: 0.76-0.99 and OR=0.91, 95% CI: 0.85-0.98, respectively). We observed that the CDH1 ?347 G/GA+GA/GA carrier had an increased risk of CRC, the summary OR was 1.33 (95% CI: 1.08-1.62). Conclusions Data indicated that certain CDH1 gene promoter ?160 C>A and ?347 G>GA variants might affect the susceptibility of CRC. Recommendations for further studies include pooling of individual data to facilitate evaluation of multigenic effects and detailed analysis of effect modification by environmental and lifestyle factors.
机译：目的已发表的关于E-cadherin（CDH1）基因启动子多态性与大肠癌（CRC）风险之间关系的数据尚无定论。为了获得更精确的关系估计，进行了荟萃分析。方法：在这项荟萃分析中，我们使用固定效应模型和随机效应模型评估了报道的CDH1基因启动子？160 C> A和？347 G> GA位点多态性与CRC风险之间关联的研究。结果：我们发现携带CDH1≥160AA（比值[OR] = 0.86，95％置信区间[95％CI]：0.75-0.98）和CA + AA（OR = 0.92，95％CI：0.87）的受试者的CRC风险降低。 -0.98），分别使用来自十项研究的4、652 / 4、428例/对照和7、866 / 7、689例/对照。我们在分层分析中发现了CDH1？160CA + AA多态性对远端站点肿瘤人群和基于人群的对照中CRC的保护作用。我们发现CDH1？160AA和CA + AA多态性对欧洲和美国人群的CRC有保护作用（分别为OR = 0.87，95％CI：0.76-0.99和OR = 0.91，95％CI：0.85-0.98）。我们观察到CDH1〜347 G / GA + GA / GA携带者患CRC的风险增加，总OR为1.33（95％CI：1.08-1.62）。结论数据表明某些CDH1基因启动子？160 C> A和？347 G> GA变异可能影响CRC的易感性。对于进一步研究的建议包括合并单个数据以促进对多基因效应的评估，以及通过环境和生活方式因素对效应修饰的详细分析。

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