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首页> 外文期刊>International journal of colorectal disease. >Comparison between quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and results of histopathological scoring in ulcerative colitis
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Comparison between quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and results of histopathological scoring in ulcerative colitis

机译：超声造影定量评估肠壁血管化与溃疡性结肠炎组织病理学评分结果的比较

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Purpose: In ulcerative colitis (UC), endoscopic methods are preferred for assessment of extent and activity of disease. Due to the invasive nature of endoscopical examinations, replacement by other, reliable imaging procedures would be helpful. Contrast-enhanced ultrasound (CEUS) in combination with perfusion assessment using a specific quantification software might be such a new diagnostic tool. Thus, we compared the findings of CEUS with the results of endoscopically taken specimens applying a histopathological scoring system. Methods: We prospectively evaluated 15 patients with proven UC undergoing endoscopy. CEUS was performed and the quantification software Qontrast? applied to obtain contrast-enhanced sonographic perfusion maps. Moreover, in each patient C-reactive protein (CRP) was measured and taken biopsies were assessed using an advanced scoring system. Four patients had to be excluded from final analysis. Results: There was a trend to higher Peak (%) values with increasing histological inflammation. Furthermore, a strong negative correlation between the ratio TTP (s)/Peak (%) (Spearman's correlation r=?0.761, p<0.01) was found. There was no significant relationship between CRP and histopathological scoring or CEUS parameters, respectively. Conclusion: Quantitative evaluation with CEUS, particularly the calculation of the ratio TTP (s)/Peak (%), provides a simple method for assessment of inflammatory activity in UC.
机译：目的：在溃疡性结肠炎（UC）中，首选内窥镜检查方法来评估疾病的程度和活动。由于内窥镜检查的侵入性，用其他可靠的影像学检查替代将很有帮助。造影增强超声（CEUS）结合使用特定定量软件进行的灌注评估可能是这样一种新的诊断工具。因此，我们将CEUS的发现与应用组织病理学评分系统的内镜取标本的结果进行了比较。方法：我们前瞻性评估了15例经证实的UC接受内镜检查的患者。进行了CEUS和定量软件Qontrast？用于获取造影剂超声造影图。此外，对每位患者的C反应蛋白（CRP）进行了测量，并使用高级评分系统对所取活检进行了评估。必须将四名患者排除在最终分析之外。结果：随着组织学炎症的增加，存在峰值（％）值较高的趋势。此外，发现比率TTP（s）/峰（％）之间具有很强的负相关性（Spearman相关性r ＝≤0.761，p ＜0.01）。 CRP和组织病理学评分或CEUS参数之间没有显着关系。结论：CEUS的定量评估，特别是TTP /峰值（％）之比的计算，为评估UC的炎症活性提供了一种简单的方法。

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