...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of colorectal disease. >Clinical features and treatment of ulcerative colitis-related severe gastroduodenitis and enteritis with massive bleeding after colectomy
【24h】

Clinical features and treatment of ulcerative colitis-related severe gastroduodenitis and enteritis with massive bleeding after colectomy

机译：溃疡性结肠炎相关的严重胃十二指肠炎和肠炎伴结肠切除术后大出血的临床特点和治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Ulcerative colitis (UC) has been recognised as a systemic immune disorder that is not as restricted as colitis. UC-related gastrointestinal lesions with bleeding can develop soon after colectomy and can progress rapidly. Therefore, we considered the clinical features and treatment of these UC-related lesions. Methods: We reviewed the patient data in our UC surgery database to evaluate its prevalence and features. Results: We found 7/1,100 patients with UC-related lesions between January 2000 and April 2013. These lesions developed at a mean of 24 (range 8-480) days after colectomy. Six of the seven patients suffered from gastrointestinal bleeding as an initial symptom that rapidly developed into massive bleeding or perforations. All of the patients were diagnosed with pancolitis; at the time of colectomy, fulminant, severe, moderate, and mild colitis were presented by four, one, one, and one patients, respectively. All patients with enteritis had consecutively developed other infectious complications, including anastomotic leakage, pyoderma gangrenosum, wound infection, and pneumonia. Although patients with bleeding did not respond to treatment with corticosteroids, they responded well to infliximab soon after its administration. Although six of the seven patients showed cytomegalo virus re-activation in blood or pathological examinations, ganciclovir was not effective in its elimination. Conclusion: Although UC-related lesions with an unknown aetiology can occur after colectomy, immediate examination and treatment are required if gastrointestinal bleeding is found after surgery. Because gastrointestinal bleeding from UC-related lesions can worsen rapidly and may be related to mortality, early potent immunosuppressive therapy should be considered.
机译：简介：溃疡性结肠炎（UC）被认为是一种全身性免疫疾病，并不像结肠炎那样受到局限。结肠切除术后不久便会出现UC相关的胃肠道出血伴出血，并且进展迅速。因此，我们考虑了这些与UC相关的病变的临床特征和治疗。方法：我们在UC手术数据库中检查了患者数据，以评估其患病率和特征。结果：我们发现2000年1月至2013年4月之间有UC相关病变的7 / 1,100例患者。这些病变平均在结肠切除术后24天（8-480范围）内发展。七名患者中有六名患有胃肠道出血，最初症状是迅速发展为大量出血或穿孔。所有患者均被诊断为胰腺炎。在结肠切除术时，分别有四，一，一和一例患者出现暴发性，重度，中度和轻度结肠炎。所有患有肠炎的患者都连续发生其他感染并发症，包括吻合口漏，坏疽性脓皮病，伤口感染和肺炎。尽管出血患者对皮质类固醇激素治疗无反应，但英夫利昔单抗给药后不久反应良好。尽管七名患者中有六名在血液或病理学检查中显示巨细胞病毒重新激活，但更昔洛韦仍无法有效消除。结论：尽管结肠切除术后可能会发生病因不明的UC相关病变，但如果手术后发现胃肠道出血，则需要立即检查和治疗。由于UC相关病变引起的胃肠道出血会迅速恶化并可能与死亡率相关，因此应考虑早期有效的免疫抑制治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号