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首页> 外文期刊>International journal of computational biology and drug design >Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line
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Inference of hierarchical regulatory network of TCF7L2 binding sites in MCF7 cell line

机译：MCF7细胞系中TCF7L2结合位点的分层调控网络的推论

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摘要

The TCF7L2 transcription factor (TF) is a member of Wnt signalling pathway, and may influence transcription of several genes by binding to distinct regulatory regions. Genome-wide studies have identified thousands of TCF7L2 binding sites and have revealed some associated TF partners. However, there is still a large uncharted region in the hierarchical regulatory network for TCF7L2 and the partner TFs in MCF7 cells. We analysed ChlP-seq data by searching for motifs in the enriched peak region based on TF-specific position weight matrix (PWM). We found association of FOXO1 and CAD with up-regulated genes, AP2a, PBF and API with down-regulated genes. TCF7L2 and GAT A3 were found to be associated with both up and down-regulated genes. Our study uncovers new TCF7L2 associated regulatory networks by mining ChlP-seq data in MCF7 cell, which may contribute to further study of the mechanisms related to Wnt pathway in breast cancer or other diseases.
机译：TCF7L2转录因子（TF）是Wnt信号通路的成员，并可能通过与不同的调控区结合而影响多个基因的转录。全基因组研究确定了数千个TCF7L2结合位点，并揭示了一些相关的TF伴侣。但是，在TCF7L2和MCF7单元中的伙伴TF的分层监管网络中仍然存在较大的未知领域。我们通过基于TF特定位置权重矩阵（PWM）搜索富集峰区域中的图案来分析ChlP-seq数据。我们发现FOXO1和CAD与上调基因有关，AP2a，PBF和API与下调基因有关。发现TCF7L2和GAT A3与上调和下调的基因都相关。我们的研究通过挖掘MCF7细胞中的ChlP-seq数据发现了新的TCF7L2相关调控网络，这可能有助于进一步研究与乳腺癌或其他疾病中Wnt途径相关的机制。

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