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Biodegradable magnesium coronary stents: material, design and fabrication

机译:可生物降解的镁冠状动脉支架:材料,设计和制造

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摘要

Biodegradable cardiovascular stents in magnesium (Mg) alloys constitute a promising option for a less intrusive treatment, due to their high compatibility with the body tissue and intrinsic dissolution in body fluids. The design and fabrication aspects of this medical device require an integrated approach considering different aspects such as mechanical properties, corrosion behaviour and biocompatibility. This work gathers and summarises a multidisciplinary work carried out by three different research teams for the design and fabrication of Mg stents. In particular, the paper discusses the design of the novel stent mesh, the deformability study of the Mg alloys for tubular raw material and laser microcutting for the realisation of the stent mesh. Although, the results are not fully validated as the device has not been fully tested, they show the feasibility of the used approaches, as the first prototype stents in Mg alloy were produced successfully.
机译:由于镁(Mg)合金与人体组织的高度相容性以及其在体液中的固有溶解性,因此镁(Mg)合金中的可生物降解的心血管支架构成了一种较有前景的治疗选择。这种医疗设备的设计和制造方面需要综合考虑各种方面的综合方法,例如机械性能,腐蚀行为和生物相容性。这项工作收集并总结了由三个不同的研究团队针对Mg支架的设计和制造进行的多学科研究。特别是,本文讨论了新型支架网的设计,用于管状原材料的镁合金的变形性研究以及用于实现支架网的激光微切割。尽管由于未对设备进行全面测试,结果尚未得到充分验证,但它们证明了所用方法的可行性,因为成功生产出了第一批镁合金原型支架。

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